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Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology

Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while the entorhinal cortex (EC) is one of the most vulnerable regions. Using a knock-in AD mouse model (App KI), we show that within the cerebellum, the deep...

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Detalles Bibliográficos
Autores principales: Gaunt, Jessica R., Zainolabidin, Norliyana, Yip, Alaric K. K., Tan, Jia Min, Low, Aloysius Y. T., Chen, Albert I., Ch’ng, Toh Hean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656954/
https://www.ncbi.nlm.nih.gov/pubmed/37978387
http://dx.doi.org/10.1186/s12974-023-02913-8