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Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus

INTRODUCTION: Cardiac autonomic neuropathy (CAN) is one of the microvascular complications of diabetes mellitus, which is due to the involvement of autonomic nerve fibers innervating the heart and blood vessels. CAN was found to have a greater degree of morbidity and mortality than their non-CAN cou...

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Autores principales: Karthikeyan, Aditya, Manjunath, PR, Latha, A Tharuni, Sultana, Sana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657038/
https://www.ncbi.nlm.nih.gov/pubmed/38024922
http://dx.doi.org/10.4103/jfmpc.jfmpc_609_23
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author Karthikeyan, Aditya
Manjunath, PR
Latha, A Tharuni
Sultana, Sana
author_facet Karthikeyan, Aditya
Manjunath, PR
Latha, A Tharuni
Sultana, Sana
author_sort Karthikeyan, Aditya
collection PubMed
description INTRODUCTION: Cardiac autonomic neuropathy (CAN) is one of the microvascular complications of diabetes mellitus, which is due to the involvement of autonomic nerve fibers innervating the heart and blood vessels. CAN was found to have a greater degree of morbidity and mortality than their non-CAN counterparts as it is underdiagnosed. Hence, this study aims to determine the prevalence and severity of CAN in type 2 diabetics in the South Indian setting. MATERIALS AND METHODS: Forty-two patients with type 2 diabetes mellitus were enrolled in the study. Patients underwent tests for CAN, with the severity of CAN estimated as a CAN score, which was the sum of the scores of the four cardiovascular autonomic function tests. RESULTS: Out of the 42 patients, a total of 36 patients (85.7%) were diagnosed with CAN. Among those with CAN, 24 patients had early CAN (57.1%), and 12 were diagnosed with definite CAN (28.6%). Patients with any form of CAN (early and definite CAN) had higher HbA1c and mean glucose values than those without CAN. CAN was also found to be more severe among older patients with diabetes. CONCLUSION: In the present study, we found that more than 50% of the study population had early CAN and around 28.6% patients had definite CAN indicating higher prevalence of CAN in our population. Also, there was a positive correlation between the severity of CAN and the age of the patients. This study highlights the importance of understanding the importance of screening the diabetic patients for CAN to prevent adverse cardiovascular events.
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spelling pubmed-106570382023-09-01 Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus Karthikeyan, Aditya Manjunath, PR Latha, A Tharuni Sultana, Sana J Family Med Prim Care Original Article INTRODUCTION: Cardiac autonomic neuropathy (CAN) is one of the microvascular complications of diabetes mellitus, which is due to the involvement of autonomic nerve fibers innervating the heart and blood vessels. CAN was found to have a greater degree of morbidity and mortality than their non-CAN counterparts as it is underdiagnosed. Hence, this study aims to determine the prevalence and severity of CAN in type 2 diabetics in the South Indian setting. MATERIALS AND METHODS: Forty-two patients with type 2 diabetes mellitus were enrolled in the study. Patients underwent tests for CAN, with the severity of CAN estimated as a CAN score, which was the sum of the scores of the four cardiovascular autonomic function tests. RESULTS: Out of the 42 patients, a total of 36 patients (85.7%) were diagnosed with CAN. Among those with CAN, 24 patients had early CAN (57.1%), and 12 were diagnosed with definite CAN (28.6%). Patients with any form of CAN (early and definite CAN) had higher HbA1c and mean glucose values than those without CAN. CAN was also found to be more severe among older patients with diabetes. CONCLUSION: In the present study, we found that more than 50% of the study population had early CAN and around 28.6% patients had definite CAN indicating higher prevalence of CAN in our population. Also, there was a positive correlation between the severity of CAN and the age of the patients. This study highlights the importance of understanding the importance of screening the diabetic patients for CAN to prevent adverse cardiovascular events. Wolters Kluwer - Medknow 2023-09 2023-09-30 /pmc/articles/PMC10657038/ /pubmed/38024922 http://dx.doi.org/10.4103/jfmpc.jfmpc_609_23 Text en Copyright: © 2023 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Karthikeyan, Aditya
Manjunath, PR
Latha, A Tharuni
Sultana, Sana
Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
title Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
title_full Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
title_fullStr Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
title_full_unstemmed Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
title_short Prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
title_sort prevalence of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657038/
https://www.ncbi.nlm.nih.gov/pubmed/38024922
http://dx.doi.org/10.4103/jfmpc.jfmpc_609_23
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