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Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study

BACKGROUND: Pruritus is a frequent complaint associated with various inflammatory dermatoses. Sleep is often disturbed because of pruritus but the impact of severity and diurnal pattern of pruritus has not been studied so far. OBJECTIVES: To estimate the prevalence of nocturnal itch (NI) and its ass...

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Autores principales: Shukla, Prakriti, Verma, Parul, Tripathi, Srishti, Dwivedi, Alok K., Shukla, Mukesh, Suvirya, Swastika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657069/
https://www.ncbi.nlm.nih.gov/pubmed/38024914
http://dx.doi.org/10.4103/jfmpc.jfmpc_2425_22
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author Shukla, Prakriti
Verma, Parul
Tripathi, Srishti
Dwivedi, Alok K.
Shukla, Mukesh
Suvirya, Swastika
author_facet Shukla, Prakriti
Verma, Parul
Tripathi, Srishti
Dwivedi, Alok K.
Shukla, Mukesh
Suvirya, Swastika
author_sort Shukla, Prakriti
collection PubMed
description BACKGROUND: Pruritus is a frequent complaint associated with various inflammatory dermatoses. Sleep is often disturbed because of pruritus but the impact of severity and diurnal pattern of pruritus has not been studied so far. OBJECTIVES: To estimate the prevalence of nocturnal itch (NI) and its association with itch severity, sleep disturbance and quality of life (QoL) compared with non-NI in chronic plaque psoriasis (CPP) and chronic spontaneous urticaria (CSU). METHODS: We performed a cross-sectional study in patients aged ≥18 years with CPP or CSU for at least 6 weeks. A comprehensive in-house questionnaire designed for study formed the basis for categorizing patients into NI and non-NI. Validated instruments like visual analog scale, pruritus grading system, General Sleep Disturbance Scale, and Dermatology life quality index were used to assess itch severity, sleep, and QoL. RESULTS: A total of 255 patients (CPP: 131; CSU: 124) were included in this study. Prevalence of NI was 43.5% (95% confidence interval: 34.9%-52.4%) in CPP and 29% (95% confidence interval: 21.2%-37.9%) in CSU. NI was strongly associated with higher pruritus grading system scores in CSU and CPP (regression coefficient = 1.5, P =0.004 and regression coefficient = 1.3, P =0.004, respectively), with impaired sleep (OR = 2.97, P = 0.025) in CPP and with itch-affected sleep in CSU. Itch severity was associated with impaired sleep; however, the association was modified by the presence of NI in CSU patients. CONCLUSION: Nocturnal itch is prevalent in chronic dermatoses and significant for sleep deficit and impaired QoL. Early screening and management of sleep disturbance among patients presenting with nocturnal itch should be routinely undertaken.
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spelling pubmed-106570692023-09-01 Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study Shukla, Prakriti Verma, Parul Tripathi, Srishti Dwivedi, Alok K. Shukla, Mukesh Suvirya, Swastika J Family Med Prim Care Original Article BACKGROUND: Pruritus is a frequent complaint associated with various inflammatory dermatoses. Sleep is often disturbed because of pruritus but the impact of severity and diurnal pattern of pruritus has not been studied so far. OBJECTIVES: To estimate the prevalence of nocturnal itch (NI) and its association with itch severity, sleep disturbance and quality of life (QoL) compared with non-NI in chronic plaque psoriasis (CPP) and chronic spontaneous urticaria (CSU). METHODS: We performed a cross-sectional study in patients aged ≥18 years with CPP or CSU for at least 6 weeks. A comprehensive in-house questionnaire designed for study formed the basis for categorizing patients into NI and non-NI. Validated instruments like visual analog scale, pruritus grading system, General Sleep Disturbance Scale, and Dermatology life quality index were used to assess itch severity, sleep, and QoL. RESULTS: A total of 255 patients (CPP: 131; CSU: 124) were included in this study. Prevalence of NI was 43.5% (95% confidence interval: 34.9%-52.4%) in CPP and 29% (95% confidence interval: 21.2%-37.9%) in CSU. NI was strongly associated with higher pruritus grading system scores in CSU and CPP (regression coefficient = 1.5, P =0.004 and regression coefficient = 1.3, P =0.004, respectively), with impaired sleep (OR = 2.97, P = 0.025) in CPP and with itch-affected sleep in CSU. Itch severity was associated with impaired sleep; however, the association was modified by the presence of NI in CSU patients. CONCLUSION: Nocturnal itch is prevalent in chronic dermatoses and significant for sleep deficit and impaired QoL. Early screening and management of sleep disturbance among patients presenting with nocturnal itch should be routinely undertaken. Wolters Kluwer - Medknow 2023-09 2023-09-30 /pmc/articles/PMC10657069/ /pubmed/38024914 http://dx.doi.org/10.4103/jfmpc.jfmpc_2425_22 Text en Copyright: © 2023 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shukla, Prakriti
Verma, Parul
Tripathi, Srishti
Dwivedi, Alok K.
Shukla, Mukesh
Suvirya, Swastika
Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
title Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
title_full Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
title_fullStr Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
title_full_unstemmed Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
title_short Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
title_sort association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657069/
https://www.ncbi.nlm.nih.gov/pubmed/38024914
http://dx.doi.org/10.4103/jfmpc.jfmpc_2425_22
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