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Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology
Inorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing attention due to the many functions it appears to perform within mammalian cells. This essay does not aim to systematically review the copious mammalian polyP literature. Instead, we examined polyP synthesis...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657179/ https://www.ncbi.nlm.nih.gov/pubmed/37844192 http://dx.doi.org/10.1042/BST20230483 |
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author | Borghi, Filipy Saiardi, Adolfo |
author_facet | Borghi, Filipy Saiardi, Adolfo |
author_sort | Borghi, Filipy |
collection | PubMed |
description | Inorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing attention due to the many functions it appears to perform within mammalian cells. This essay does not aim to systematically review the copious mammalian polyP literature. Instead, we examined polyP synthesis and functions in various microorganisms and used an evolutionary perspective to theorise key issues of this field and propose solutions. By highlighting the presence of VTC4 in distinct species of very divergent eucaryote clades (Opisthokonta, Viridiplantae, Discoba, and the SAR), we propose that whilst polyP synthesising machinery was present in the ancestral eukaryote, most lineages subsequently lost it during evolution. The analysis of the bacteria-acquired amoeba PPK1 and its unique polyP physiology suggests that eukaryote cells must have developed mechanisms to limit cytosolic polyP accumulation. We reviewed the literature on polyP in the mitochondria from the perspective of its endosymbiotic origin from bacteria, highlighting how mitochondria could possess a polyP physiology reminiscent of their ‘bacterial’ beginning that is not yet investigated. Finally, we emphasised the similarities that the anionic polyP shares with the better-understood negatively charged polymers DNA and RNA, postulating that the nucleus offers an ideal environment where polyP physiology might thrive. |
format | Online Article Text |
id | pubmed-10657179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106571792023-10-16 Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology Borghi, Filipy Saiardi, Adolfo Biochem Soc Trans Review Articles Inorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing attention due to the many functions it appears to perform within mammalian cells. This essay does not aim to systematically review the copious mammalian polyP literature. Instead, we examined polyP synthesis and functions in various microorganisms and used an evolutionary perspective to theorise key issues of this field and propose solutions. By highlighting the presence of VTC4 in distinct species of very divergent eucaryote clades (Opisthokonta, Viridiplantae, Discoba, and the SAR), we propose that whilst polyP synthesising machinery was present in the ancestral eukaryote, most lineages subsequently lost it during evolution. The analysis of the bacteria-acquired amoeba PPK1 and its unique polyP physiology suggests that eukaryote cells must have developed mechanisms to limit cytosolic polyP accumulation. We reviewed the literature on polyP in the mitochondria from the perspective of its endosymbiotic origin from bacteria, highlighting how mitochondria could possess a polyP physiology reminiscent of their ‘bacterial’ beginning that is not yet investigated. Finally, we emphasised the similarities that the anionic polyP shares with the better-understood negatively charged polymers DNA and RNA, postulating that the nucleus offers an ideal environment where polyP physiology might thrive. Portland Press Ltd. 2023-10-31 2023-10-16 /pmc/articles/PMC10657179/ /pubmed/37844192 http://dx.doi.org/10.1042/BST20230483 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. |
spellingShingle | Review Articles Borghi, Filipy Saiardi, Adolfo Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology |
title | Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology |
title_full | Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology |
title_fullStr | Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology |
title_full_unstemmed | Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology |
title_short | Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology |
title_sort | evolutionary perspective on mammalian inorganic polyphosphate (polyp) biology |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657179/ https://www.ncbi.nlm.nih.gov/pubmed/37844192 http://dx.doi.org/10.1042/BST20230483 |
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