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Insights into the function of cytoglobin
Since its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive in vitro and in vivo research, a range of potential physiological and pathological mechanisms has emerged for this multifunctional member of the hemoglobin family. Currently, over 200 research publication...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Portland Press Ltd.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657185/ https://www.ncbi.nlm.nih.gov/pubmed/37721133 http://dx.doi.org/10.1042/BST20230081 |
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author | Reeder, Brandon J. |
author_facet | Reeder, Brandon J. |
author_sort | Reeder, Brandon J. |
collection | PubMed |
description | Since its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive in vitro and in vivo research, a range of potential physiological and pathological mechanisms has emerged for this multifunctional member of the hemoglobin family. Currently, over 200 research publications have examined different aspects of cytoglobin structure, redox chemistry and potential roles in cell signalling pathways. This research is wide ranging, but common themes have emerged throughout the research. This review examines the current structural, biochemical and in vivo knowledge of cytoglobin published over the past two decades. Radical scavenging, nitric oxide homeostasis, lipid binding and oxidation and the role of an intramolecular disulfide bond on the redox chemistry are examined, together with aspects and roles for Cygb in cancer progression and liver fibrosis. |
format | Online Article Text |
id | pubmed-10657185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106571852023-09-18 Insights into the function of cytoglobin Reeder, Brandon J. Biochem Soc Trans Review Articles Since its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive in vitro and in vivo research, a range of potential physiological and pathological mechanisms has emerged for this multifunctional member of the hemoglobin family. Currently, over 200 research publications have examined different aspects of cytoglobin structure, redox chemistry and potential roles in cell signalling pathways. This research is wide ranging, but common themes have emerged throughout the research. This review examines the current structural, biochemical and in vivo knowledge of cytoglobin published over the past two decades. Radical scavenging, nitric oxide homeostasis, lipid binding and oxidation and the role of an intramolecular disulfide bond on the redox chemistry are examined, together with aspects and roles for Cygb in cancer progression and liver fibrosis. Portland Press Ltd. 2023-10-31 2023-09-18 /pmc/articles/PMC10657185/ /pubmed/37721133 http://dx.doi.org/10.1042/BST20230081 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of Essex in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. |
spellingShingle | Review Articles Reeder, Brandon J. Insights into the function of cytoglobin |
title | Insights into the function of cytoglobin |
title_full | Insights into the function of cytoglobin |
title_fullStr | Insights into the function of cytoglobin |
title_full_unstemmed | Insights into the function of cytoglobin |
title_short | Insights into the function of cytoglobin |
title_sort | insights into the function of cytoglobin |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657185/ https://www.ncbi.nlm.nih.gov/pubmed/37721133 http://dx.doi.org/10.1042/BST20230081 |
work_keys_str_mv | AT reederbrandonj insightsintothefunctionofcytoglobin |