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Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report
Efficient and rapid identification of active SARS-CoV-2 infections has been key to monitoring and mitigating the spread of the virus. The implementation of nucleic acid testing (e.g., RT-PCR) was broadly adopted by most public health organizations at the national and community levels across the glob...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657208/ https://www.ncbi.nlm.nih.gov/pubmed/38026284 http://dx.doi.org/10.3389/fpubh.2023.1240308 |
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author | Galipeau, Yannick Xavier, Abishek Dyks, Aaron Cooper, Curtis Langlois, Marc-André |
author_facet | Galipeau, Yannick Xavier, Abishek Dyks, Aaron Cooper, Curtis Langlois, Marc-André |
author_sort | Galipeau, Yannick |
collection | PubMed |
description | Efficient and rapid identification of active SARS-CoV-2 infections has been key to monitoring and mitigating the spread of the virus. The implementation of nucleic acid testing (e.g., RT-PCR) was broadly adopted by most public health organizations at the national and community levels across the globe, which was followed by more accessible means of home testing including lateral flow immunochromatographic assay (LFA), also known as a rapid antigen test. Here we report the case of an adult female who repeatedly and consecutively tested positive by RAT (BTNX inc). This sustained false positive was not linked with an active SARS-CoV-2 infection, which was ruled out by RT-PCR and serological analyses. SARS-CoV-2 serology revealed no detectable levels of antibodies against the nucleocapsid suggesting no recent prior infection by SARS-CoV-2. This continuous false positive was limited to BTNX testing devices. This case report aims to describe that such continuous false positives can occur and describes alternative testing approaches that can be performed to confirm RAT results. In addition, broader awareness of such occurrences is warranted in the healthcare and public health community to avoid unnecessary negative impacts on individual’s day to day life. |
format | Online Article Text |
id | pubmed-10657208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106572082023-11-03 Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report Galipeau, Yannick Xavier, Abishek Dyks, Aaron Cooper, Curtis Langlois, Marc-André Front Public Health Public Health Efficient and rapid identification of active SARS-CoV-2 infections has been key to monitoring and mitigating the spread of the virus. The implementation of nucleic acid testing (e.g., RT-PCR) was broadly adopted by most public health organizations at the national and community levels across the globe, which was followed by more accessible means of home testing including lateral flow immunochromatographic assay (LFA), also known as a rapid antigen test. Here we report the case of an adult female who repeatedly and consecutively tested positive by RAT (BTNX inc). This sustained false positive was not linked with an active SARS-CoV-2 infection, which was ruled out by RT-PCR and serological analyses. SARS-CoV-2 serology revealed no detectable levels of antibodies against the nucleocapsid suggesting no recent prior infection by SARS-CoV-2. This continuous false positive was limited to BTNX testing devices. This case report aims to describe that such continuous false positives can occur and describes alternative testing approaches that can be performed to confirm RAT results. In addition, broader awareness of such occurrences is warranted in the healthcare and public health community to avoid unnecessary negative impacts on individual’s day to day life. Frontiers Media S.A. 2023-11-03 /pmc/articles/PMC10657208/ /pubmed/38026284 http://dx.doi.org/10.3389/fpubh.2023.1240308 Text en Copyright © 2023 Galipeau, Xavier, Dyks, Cooper and Langlois. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Galipeau, Yannick Xavier, Abishek Dyks, Aaron Cooper, Curtis Langlois, Marc-André Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report |
title | Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report |
title_full | Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report |
title_fullStr | Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report |
title_full_unstemmed | Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report |
title_short | Continuous false positive results by SARS-CoV-2 rapid antigen testing: a case report |
title_sort | continuous false positive results by sars-cov-2 rapid antigen testing: a case report |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657208/ https://www.ncbi.nlm.nih.gov/pubmed/38026284 http://dx.doi.org/10.3389/fpubh.2023.1240308 |
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