Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature

Acute myeloid leukemia (AML) with the high-risk variant inv(3)/t(3;3) or t(3;3)(q21;26.2) is rarely seen in the pediatric and young adult population. It is associated with poor outcomes with ineffective therapeutic options. Here, we present a case of an 18-year-old female with treatment refractory i...

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Detalles Bibliográficos
Autores principales: Blakemore, Carlee, Damodharan, Sudarshawn, Puccetti, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657244/
https://www.ncbi.nlm.nih.gov/pubmed/38026762
http://dx.doi.org/10.1155/2023/6628492
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author Blakemore, Carlee
Damodharan, Sudarshawn
Puccetti, Diane
author_facet Blakemore, Carlee
Damodharan, Sudarshawn
Puccetti, Diane
author_sort Blakemore, Carlee
collection PubMed
description Acute myeloid leukemia (AML) with the high-risk variant inv(3)/t(3;3) or t(3;3)(q21;26.2) is rarely seen in the pediatric and young adult population. It is associated with poor outcomes with ineffective therapeutic options. Here, we present a case of an 18-year-old female with treatment refractory inv(3) AML in whom remission was unable to be obtained. Better treatment options are needed given the increased resistance to traditional therapy this subtype portrays. Here, we review the literature on pediatric and young adult inv(3) AML along with newer therapeutic options.
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spelling pubmed-106572442023-11-11 Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature Blakemore, Carlee Damodharan, Sudarshawn Puccetti, Diane Case Rep Oncol Med Case Report Acute myeloid leukemia (AML) with the high-risk variant inv(3)/t(3;3) or t(3;3)(q21;26.2) is rarely seen in the pediatric and young adult population. It is associated with poor outcomes with ineffective therapeutic options. Here, we present a case of an 18-year-old female with treatment refractory inv(3) AML in whom remission was unable to be obtained. Better treatment options are needed given the increased resistance to traditional therapy this subtype portrays. Here, we review the literature on pediatric and young adult inv(3) AML along with newer therapeutic options. Hindawi 2023-11-11 /pmc/articles/PMC10657244/ /pubmed/38026762 http://dx.doi.org/10.1155/2023/6628492 Text en Copyright © 2023 Carlee Blakemore et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Blakemore, Carlee
Damodharan, Sudarshawn
Puccetti, Diane
Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature
title Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature
title_full Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature
title_fullStr Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature
title_full_unstemmed Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature
title_short Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature
title_sort inv(3) acute myeloid leukemia in a young adult and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657244/
https://www.ncbi.nlm.nih.gov/pubmed/38026762
http://dx.doi.org/10.1155/2023/6628492
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