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A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition
The longstanding idea that the cerebral cortex is the main neural correlate of human cognition can be elaborated by comparative analyses along the vertebrate phylogenetic tree that support the view that the cerebello-cerebral system is suited to support non-motor functions more generally. In humans,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657313/ https://www.ncbi.nlm.nih.gov/pubmed/36417091 http://dx.doi.org/10.1007/s12311-022-01495-0 |
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author | Magielse, Neville Heuer, Katja Toro, Roberto Schutter, Dennis J. L. G. Valk, Sofie L. |
author_facet | Magielse, Neville Heuer, Katja Toro, Roberto Schutter, Dennis J. L. G. Valk, Sofie L. |
author_sort | Magielse, Neville |
collection | PubMed |
description | The longstanding idea that the cerebral cortex is the main neural correlate of human cognition can be elaborated by comparative analyses along the vertebrate phylogenetic tree that support the view that the cerebello-cerebral system is suited to support non-motor functions more generally. In humans, diverse accounts have illustrated cerebellar involvement in cognitive functions. Although the neocortex, and its transmodal association cortices such as the prefrontal cortex, have become disproportionately large over primate evolution specifically, human neocortical volume does not appear to be exceptional relative to the variability within primates. Rather, several lines of evidence indicate that the exceptional volumetric increase of the lateral cerebellum in conjunction with its connectivity with the cerebral cortical system may be linked to non-motor functions and mental operation in primates. This idea is supported by diverging cerebello-cerebral adaptations that potentially coevolve with cognitive abilities across other vertebrates such as dolphins, parrots, and elephants. Modular adaptations upon the vertebrate cerebello-cerebral system may thus help better understand the neuroevolutionary trajectory of the primate brain and its relation to cognition in humans. Lateral cerebellar lobules crura I-II and their reciprocal connections to the cerebral cortical association areas appear to have substantially expanded in great apes, and humans. This, along with the notable increase in the ventral portions of the dentate nucleus and a shift to increased relative prefrontal-cerebellar connectivity, suggests that modular cerebellar adaptations support cognitive functions in humans. In sum, we show how comparative neuroscience provides new avenues to broaden our understanding of cerebellar and cerebello-cerebral functions in the context of cognition. |
format | Online Article Text |
id | pubmed-10657313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-106573132022-11-23 A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition Magielse, Neville Heuer, Katja Toro, Roberto Schutter, Dennis J. L. G. Valk, Sofie L. Cerebellum Review The longstanding idea that the cerebral cortex is the main neural correlate of human cognition can be elaborated by comparative analyses along the vertebrate phylogenetic tree that support the view that the cerebello-cerebral system is suited to support non-motor functions more generally. In humans, diverse accounts have illustrated cerebellar involvement in cognitive functions. Although the neocortex, and its transmodal association cortices such as the prefrontal cortex, have become disproportionately large over primate evolution specifically, human neocortical volume does not appear to be exceptional relative to the variability within primates. Rather, several lines of evidence indicate that the exceptional volumetric increase of the lateral cerebellum in conjunction with its connectivity with the cerebral cortical system may be linked to non-motor functions and mental operation in primates. This idea is supported by diverging cerebello-cerebral adaptations that potentially coevolve with cognitive abilities across other vertebrates such as dolphins, parrots, and elephants. Modular adaptations upon the vertebrate cerebello-cerebral system may thus help better understand the neuroevolutionary trajectory of the primate brain and its relation to cognition in humans. Lateral cerebellar lobules crura I-II and their reciprocal connections to the cerebral cortical association areas appear to have substantially expanded in great apes, and humans. This, along with the notable increase in the ventral portions of the dentate nucleus and a shift to increased relative prefrontal-cerebellar connectivity, suggests that modular cerebellar adaptations support cognitive functions in humans. In sum, we show how comparative neuroscience provides new avenues to broaden our understanding of cerebellar and cerebello-cerebral functions in the context of cognition. Springer US 2022-11-23 2023 /pmc/articles/PMC10657313/ /pubmed/36417091 http://dx.doi.org/10.1007/s12311-022-01495-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Magielse, Neville Heuer, Katja Toro, Roberto Schutter, Dennis J. L. G. Valk, Sofie L. A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition |
title | A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition |
title_full | A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition |
title_fullStr | A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition |
title_full_unstemmed | A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition |
title_short | A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition |
title_sort | comparative perspective on the cerebello-cerebral system and its link to cognition |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657313/ https://www.ncbi.nlm.nih.gov/pubmed/36417091 http://dx.doi.org/10.1007/s12311-022-01495-0 |
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