Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer

The molecular underpinnings of HER2-low and HER2-0 (IHC 0) breast tumors remain poorly defined. Using genomic findings from 1039 patients with HER2-negative metastatic breast cancer undergoing next-generation sequencing from 7/2013-12/2020, we compare results between HER2-low (n = 487, 47%) and HER2...

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Detalles Bibliográficos
Autores principales: Tarantino, P., Gupta, H., Hughes, M. E., Files, J., Strauss, S., Kirkner, G., Feeney, A.-M., Li, Y., Garrido-Castro, A. C., Barroso-Sousa, R., Bychkovsky, B. L., DiLascio, S., Sholl, L., MacConaill, L., Lindeman, N., Johnson, B. E., Meyerson, M., Jeselsohn, R., Qiu, X., Li, R., Long, H., Winer, E. P., Dillon, D., Curigliano, G., Cherniack, A. D., Tolaney, S. M., Lin, N. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657399/
https://www.ncbi.nlm.nih.gov/pubmed/37980405
http://dx.doi.org/10.1038/s41467-023-43324-w
Descripción
Sumario:The molecular underpinnings of HER2-low and HER2-0 (IHC 0) breast tumors remain poorly defined. Using genomic findings from 1039 patients with HER2-negative metastatic breast cancer undergoing next-generation sequencing from 7/2013-12/2020, we compare results between HER2-low (n = 487, 47%) and HER2-0 tumors (n = 552, 53%). A significantly higher number of ERBB2 alleles (median copy count: 2.05) are observed among HER2-low tumors compared to HER2-0 (median copy count: 1.79; P = 2.36e-6), with HER2-0 tumors harboring a higher rate of ERBB2 hemideletions (31.1% vs. 14.5%). No other genomic alteration reaches significance after accounting for multiple hypothesis testing, and no significant differences in tumor mutational burden are observed between HER2-low and HER2-0 tumors (median: 7.26 mutations/megabase vs. 7.60 mutations/megabase, p = 0.24). Here, we show that the genomic landscape of HER2-low and HER2-0 tumors does not differ significantly, apart from a higher ERBB2 copy count among HER2-low tumors, and a higher rate of ERBB2 hemideletions in HER2-0 tumors.

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