LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation

Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is highly expressed in GSCs compared to differentiated glioma cells (DGCs) and promotes GSC self-renewal and tumorigenicity...

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Detalles Bibliográficos
Autores principales: Liu, Lihui, Liu, Ziyang, Liu, Qinghua, Wu, Wei, Lin, Peng, Liu, Xing, Zhang, Yuechuan, Wang, Dongpeng, Prager, Briana C., Gimple, Ryan C., Yu, Jichuan, Zhao, Weixi, Wu, Qiulian, Zhang, Wei, Wu, Erzhong, Chen, Xiaomin, Luo, Jianjun, Rich, Jeremy N., Xie, Qi, Jiang, Tao, Chen, Runsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657414/
https://www.ncbi.nlm.nih.gov/pubmed/37980347
http://dx.doi.org/10.1038/s41467-023-43113-5

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