Genome-wide CRISPR off-target prediction and optimization using RNA-DNA interaction fingerprints

The powerful CRISPR genome editing system is hindered by its off-target effects, and existing computational tools achieved limited performance in genome-wide off-target prediction due to the lack of deep understanding of the CRISPR molecular mechanism. In this study, we propose to incorporate molecu...

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Detalles Bibliográficos
Autores principales: Chen, Qinchang, Chuai, Guohui, Zhang, Haihang, Tang, Jin, Duan, Liwen, Guan, Huan, Li, Wenhui, Li, Wannian, Wen, Jiaying, Zuo, Erwei, Zhang, Qing, Liu, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657421/
https://www.ncbi.nlm.nih.gov/pubmed/37980345
http://dx.doi.org/10.1038/s41467-023-42695-4

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