Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer’s Disease

Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer’s disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine and flu shots received between ages 65–75 w...

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Detalles Bibliográficos
Autores principales: Ukraintseva, Svetlana, Duan, Matt, Simanek, Amanda M., Holmes, Rachel, Bagley, Olivia, Rajendrakumar, Aravind L., Yashkin, Arseniy P., Akushevich, Igor, Tropsha, Alexander, Whitson, Heather, Yashin, Anatoliy, Arbeev, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657669/
https://www.ncbi.nlm.nih.gov/pubmed/37807778
http://dx.doi.org/10.3233/JAD-230088
Descripción
Sumario:Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer’s disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine and flu shots received between ages 65–75 with AD onset at age 75 or older, taking into account rs6859 polymorphism in NECTIN2 gene (AD risk factor). Pneumococcal vaccine, and total count of vaccinations against pneumonia and flu, were associated with lower odds of AD in carriers of rs6859 A allele, but not in non-carriers. We conclude that pneumococcal polysaccharide vaccine is a promising candidate for genotype-tailored AD prevention.

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