Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson’s Disease as a Multi-System Process

BACKGROUND: Evidence supports a role for the gut-brain axis in Parkinson’s disease (PD). Mice overexpressing human wild type α– synuclein (Thy1-haSyn) exhibit slow colonic transit prior to motor deficits, mirroring prodromal constipation in PD. Identifying molecular changes in the gut could provide...

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Detalles Bibliográficos
Autores principales: Videlock, Elizabeth J., Hatami, Asa, Zhu, Chunni, Kawaguchi, Riki, Chen, Han, Khan, Tasnin, Yehya, Ashwaq Hamid Salem, Stiles, Linsey, Joshi, Swapna, Hoffman, Jill M., Law, Ka Man, Rankin, Carl Robert, Chang, Lin, Maidment, Nigel T., John, Varghese, Geschwind, Daniel H., Pothoulakis, Charalabos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657720/
https://www.ncbi.nlm.nih.gov/pubmed/37638450
http://dx.doi.org/10.3233/JPD-223568

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