Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment

The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarc...

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Detalles Bibliográficos
Autores principales: Vassilaki, Maria, Syrjanen, Jeremy A., Krell-Roesch, Janina, Graff-Radford, Jonathan, Vemuri, Prashanthi, Scharf, Eugene L., Machulda, Mary M., Fields, Julie A., Kremers, Walter K., Lowe, Val J., Jack, Clifford R., Knopman, David S., Petersen, Ronald C., Geda, Yonas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657723/
https://www.ncbi.nlm.nih.gov/pubmed/38025797
http://dx.doi.org/10.3233/ADR-230073
Descripción
Sumario:The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI.

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