Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment

The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarc...

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Autores principales: Vassilaki, Maria, Syrjanen, Jeremy A., Krell-Roesch, Janina, Graff-Radford, Jonathan, Vemuri, Prashanthi, Scharf, Eugene L., Machulda, Mary M., Fields, Julie A., Kremers, Walter K., Lowe, Val J., Jack, Clifford R., Knopman, David S., Petersen, Ronald C., Geda, Yonas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657723/
https://www.ncbi.nlm.nih.gov/pubmed/38025797
http://dx.doi.org/10.3233/ADR-230073
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author Vassilaki, Maria
Syrjanen, Jeremy A.
Krell-Roesch, Janina
Graff-Radford, Jonathan
Vemuri, Prashanthi
Scharf, Eugene L.
Machulda, Mary M.
Fields, Julie A.
Kremers, Walter K.
Lowe, Val J.
Jack, Clifford R.
Knopman, David S.
Petersen, Ronald C.
Geda, Yonas E.
author_facet Vassilaki, Maria
Syrjanen, Jeremy A.
Krell-Roesch, Janina
Graff-Radford, Jonathan
Vemuri, Prashanthi
Scharf, Eugene L.
Machulda, Mary M.
Fields, Julie A.
Kremers, Walter K.
Lowe, Val J.
Jack, Clifford R.
Knopman, David S.
Petersen, Ronald C.
Geda, Yonas E.
author_sort Vassilaki, Maria
collection PubMed
description The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI.
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spelling pubmed-106577232023-11-03 Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment Vassilaki, Maria Syrjanen, Jeremy A. Krell-Roesch, Janina Graff-Radford, Jonathan Vemuri, Prashanthi Scharf, Eugene L. Machulda, Mary M. Fields, Julie A. Kremers, Walter K. Lowe, Val J. Jack, Clifford R. Knopman, David S. Petersen, Ronald C. Geda, Yonas E. J Alzheimers Dis Rep Short Communication The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI. IOS Press 2023-11-03 /pmc/articles/PMC10657723/ /pubmed/38025797 http://dx.doi.org/10.3233/ADR-230073 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Vassilaki, Maria
Syrjanen, Jeremy A.
Krell-Roesch, Janina
Graff-Radford, Jonathan
Vemuri, Prashanthi
Scharf, Eugene L.
Machulda, Mary M.
Fields, Julie A.
Kremers, Walter K.
Lowe, Val J.
Jack, Clifford R.
Knopman, David S.
Petersen, Ronald C.
Geda, Yonas E.
Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment
title Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment
title_full Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment
title_fullStr Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment
title_full_unstemmed Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment
title_short Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment
title_sort association of cerebrovascular imaging biomarkers, depression, and anxiety, with mild cognitive impairment
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657723/
https://www.ncbi.nlm.nih.gov/pubmed/38025797
http://dx.doi.org/10.3233/ADR-230073
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