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Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease
PURPOSE: This study evaluated the ocular surface disease (OSD), especially dry eye disease (DED) parameters by combining qualitative and quantitative tools, including tear matrix metalloproteinase 9 (MMP-9), in patients with Graves’ disease (GD) with and without Thyroid eye disease (TED). PATIENTS A...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657741/ https://www.ncbi.nlm.nih.gov/pubmed/38026592 http://dx.doi.org/10.2147/OPTH.S430861 |
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author | Riguetto, Cinthia Minatel Barbosa, Eduardo Buzolin Atihe, Camila Cristina Reis, Fabiano Alves, Mônica Zantut-Wittmann, Denise Engelbrecht |
author_facet | Riguetto, Cinthia Minatel Barbosa, Eduardo Buzolin Atihe, Camila Cristina Reis, Fabiano Alves, Mônica Zantut-Wittmann, Denise Engelbrecht |
author_sort | Riguetto, Cinthia Minatel |
collection | PubMed |
description | PURPOSE: This study evaluated the ocular surface disease (OSD), especially dry eye disease (DED) parameters by combining qualitative and quantitative tools, including tear matrix metalloproteinase 9 (MMP-9), in patients with Graves’ disease (GD) with and without Thyroid eye disease (TED). PATIENTS AND METHODS: A total of 17 active TED, 16 inactive TED, 16 GD without ophthalmopathy, and 16 healthy controls were included. All patients were assessed with CAS, ophthalmometry, qualitative tear MMP-9, Ocular Surface Disease Index (OSDI), ocular surface staining, Schirmer test, meibography, tear meniscus height, conjunctival hyperemia, and non-invasive tear film break-up time. Patients were classified into three subtypes of DED: aqueous tear deficiency, meibomian gland dysfunction (MGD) and mixed dry eye. RESULTS: Inactive TED was shown to be an associated factor with DED (odds ratio 14, confidence interval 2.24–87.24, p=0.0047), and presented more DED than healthy controls (87.5% versus 33.3%, p=0.0113). MGD was also more prevalent among these subjects than in healthy control (62.5% versus 6.7%; p=0.0273). No significant differences were found in other ophthalmological parameters, except for more intense conjunctival redness among active TED than GD without ophthalmopathy (p=0.0214). Qualitative MMP-9 test was more frequently positive in both eyes among active TED than in other groups (p < 0.0001). CONCLUSION: Patients with GD were symptomatic and presented a high prevalence of ocular surface changes and DED, particularly the subgroup with inactive TED. Tear MMP-9 detection was associated with active TED suggesting a relationship between ocular surface changes and the initial inflammatory phase of ophthalmopathy. |
format | Online Article Text |
id | pubmed-10657741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-106577412023-11-15 Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease Riguetto, Cinthia Minatel Barbosa, Eduardo Buzolin Atihe, Camila Cristina Reis, Fabiano Alves, Mônica Zantut-Wittmann, Denise Engelbrecht Clin Ophthalmol Original Research PURPOSE: This study evaluated the ocular surface disease (OSD), especially dry eye disease (DED) parameters by combining qualitative and quantitative tools, including tear matrix metalloproteinase 9 (MMP-9), in patients with Graves’ disease (GD) with and without Thyroid eye disease (TED). PATIENTS AND METHODS: A total of 17 active TED, 16 inactive TED, 16 GD without ophthalmopathy, and 16 healthy controls were included. All patients were assessed with CAS, ophthalmometry, qualitative tear MMP-9, Ocular Surface Disease Index (OSDI), ocular surface staining, Schirmer test, meibography, tear meniscus height, conjunctival hyperemia, and non-invasive tear film break-up time. Patients were classified into three subtypes of DED: aqueous tear deficiency, meibomian gland dysfunction (MGD) and mixed dry eye. RESULTS: Inactive TED was shown to be an associated factor with DED (odds ratio 14, confidence interval 2.24–87.24, p=0.0047), and presented more DED than healthy controls (87.5% versus 33.3%, p=0.0113). MGD was also more prevalent among these subjects than in healthy control (62.5% versus 6.7%; p=0.0273). No significant differences were found in other ophthalmological parameters, except for more intense conjunctival redness among active TED than GD without ophthalmopathy (p=0.0214). Qualitative MMP-9 test was more frequently positive in both eyes among active TED than in other groups (p < 0.0001). CONCLUSION: Patients with GD were symptomatic and presented a high prevalence of ocular surface changes and DED, particularly the subgroup with inactive TED. Tear MMP-9 detection was associated with active TED suggesting a relationship between ocular surface changes and the initial inflammatory phase of ophthalmopathy. Dove 2023-11-15 /pmc/articles/PMC10657741/ /pubmed/38026592 http://dx.doi.org/10.2147/OPTH.S430861 Text en © 2023 Riguetto et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Riguetto, Cinthia Minatel Barbosa, Eduardo Buzolin Atihe, Camila Cristina Reis, Fabiano Alves, Mônica Zantut-Wittmann, Denise Engelbrecht Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease |
title | Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease |
title_full | Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease |
title_fullStr | Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease |
title_full_unstemmed | Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease |
title_short | Ocular Surface Disease Related to the Inflammatory and Non-Inflammatory Phases of Thyroid Eye Disease |
title_sort | ocular surface disease related to the inflammatory and non-inflammatory phases of thyroid eye disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657741/ https://www.ncbi.nlm.nih.gov/pubmed/38026592 http://dx.doi.org/10.2147/OPTH.S430861 |
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