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Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells

PURPOSE: Intervertebral disc (IVD) degeneration, associated with aging, may cause low back pain and disability, with obesity as a significant risk factor. In a prior study, we found a positive correlation between IVD degeneration and levels of matrix metalloproteinase-1 (MMP-1) and leptin. Yet, the...

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Detalles Bibliográficos
Autores principales:	Hua, Kuo-Feng, Li, Lan-Hui, Yu, Hsin-Chiao, Wong, Wei-Ting, Hsu, Hsien-Ta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657743/ https://www.ncbi.nlm.nih.gov/pubmed/38026238 http://dx.doi.org/10.2147/JIR.S431026

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