Discovery of Fungus-Derived Nornidulin as a Novel TMEM16A Inhibitor: A Potential Therapy to Inhibit Mucus Secretion in Asthma

INTRODUCTION: Inhibition of Ca(2+)-activated transmembrane protein 16A (TMEM16A) Cl(−) channels has been proposed to alleviate mucus secretion in asthma. In this study, we identified a novel class of TMEM16A inhibitors from natural sources in airway epithelial Calu-3 cells and determine anti-asthmat...

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Detalles Bibliográficos
Autores principales: Pongkorpsakol, Pawin, Yimnual, Chantapol, Satianrapapong, Wilasinee, Worakajit, Nichakorn, Kaewin, Suchada, Saetang, Praphatsorn, Rukachaisirikul, Vatcharin, Muanprasat, Chatchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657771/
https://www.ncbi.nlm.nih.gov/pubmed/38026233
http://dx.doi.org/10.2147/JEP.S427594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657771/
https://www.ncbi.nlm.nih.gov/pubmed/38026233
http://dx.doi.org/10.2147/JEP.S427594

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