Cargando…

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives

N-Methyl-D-aspartate receptors (NMDARs) composed of different splice variants display distinct pH sensitivities and are crucial for learning and memory, as well as for inflammatory or injury processes. Dysregulation of the NMDAR has been linked to diseases like Parkinson’s, Alzheimer’s, schizophreni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ritter, Nadine, Disse, Paul, Aymanns, Isabel, Mücher, Lena, Schreiber, Julian A., Brenker, Christoph, Strünker, Timo, Schepmann, Dirk, Budde, Thomas, Strutz-Seebohm, Nathalie, Ametamey, Simon M., Wünsch, Bernhard, Seebohm, Guiscard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657792/ https://www.ncbi.nlm.nih.gov/pubmed/37542648 http://dx.doi.org/10.1007/s12035-023-03526-1

Ejemplares similares

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes
por: Ritter, Nadine, et al.
Publicado: (2023)

Knockout of the Cardiac Transcription Factor NKX2-5 Results in Stem Cell-Derived Cardiac Cells with Typical Purkinje Cell-like Signal Transduction and Extracellular Matrix Formation
por: Disse, Paul, et al.
Publicado: (2023)

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors
por: Schreiber, Julian A., et al.
Publicado: (2019)

[2.2]Paracyclophane‐Based TCN‐201 Analogs as GluN2A‐Selective NMDA Receptor Antagonists
por: Rajan, Remya, et al.
Publicado: (2021)

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis
por: Amedonu, Elsie, et al.
Publicado: (2019)

Paving the Way to Understand Autoantibody-Mediated Epilepsy on the Molecular Level
por: Seebohm, Guiscard, et al.
Publicado: (2015)

Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter
por: Schreiber, Julian Alexander, et al.
Publicado: (2023)

Klotho: A new trafficking modifier of Kv7.1/KCNE1 channels
por: Strutz-Seebohm, Nathalie, et al.
Publicado: (2014)

From iPSC towards cardiac tissue—a road under construction
por: Peischard, Stefan, et al.
Publicado: (2017)

Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system
por: Peischard, Stefan, et al.
Publicado: (2022)

Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and Therapies
por: Ho, Huyen Tran, et al.
Publicado: (2021)

NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytes
por: Matschke, Veronika, et al.
Publicado: (2015)

Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca(2+ )permeability and Mg(2+ )block
por: Cavara, Nora A, et al.
Publicado: (2010)

A benzodiazepine activator locks K(v)7.1 channels open by electro-mechanical uncoupling
por: Schreiber, Julian A., et al.
Publicado: (2022)

Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity
por: Lübke, Marco, et al.
Publicado: (2020)

Structural interplay of K(V)7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (K(V)7.1-A287T)
por: Rothenberg, Ina, et al.
Publicado: (2016)

Identification of a Novel Signaling Pathway and Its Relevance for GluA1 Recycling
por: Seebohm, Guiscard, et al.
Publicado: (2012)

The KCNE Tango – How KCNE1 Interacts with Kv7.1
por: Wrobel, Eva, et al.
Publicado: (2012)

Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
por: Epping, Lisa, et al.
Publicado: (2022)

Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue
por: Piccini, Ilaria, et al.
Publicado: (2015)

In Vitro Model Systems of Coxsackievirus B3-Induced Myocarditis: Comparison of Commonly Used Cell Lines and Characterization of CVB3-Infected iCell(®) Cardiomyocytes
por: Kraft, Lisa, et al.
Publicado: (2021)

Functional high-resolution time-course expression analysis of human embryonic stem cells undergoing cardiac induction
por: Piccini, Ilaria, et al.
Publicado: (2016)

Structural basis of PI(4,5)P(2)-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A)
por: Seebohm, Guiscard, et al.
Publicado: (2014)

Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds
por: Zhang, Yuewei, et al.
Publicado: (2020)

The Linker Pivot in Ci-VSP: The Key to Unlock Catalysis
por: Hobiger, Kirstin, et al.
Publicado: (2013)

The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease
por: Peischard, Stefan, et al.
Publicado: (2020)

Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis
por: Rohrbeck, Matthias, et al.
Publicado: (2023)

Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast K(v)7.1 Recycling
por: Piccini, Ilaria, et al.
Publicado: (2017)

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting
por: Wrobel, Eva, et al.
Publicado: (2016)

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists
por: Tewes, Bastian, et al.
Publicado: (2016)

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn(2+) on CatSper Ca(2+) Channels in Human Sperm
por: Jeschke, Janice K., et al.
Publicado: (2021)

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols
por: Tewes, Bastian, et al.
Publicado: (2016)

Stimulation of HERG Channel Activity by β-catenin
por: Munoz, Carlos, et al.
Publicado: (2012)

Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement
por: Shi, Qiu, et al.
Publicado: (2022)

Allosteric Inhibitors of NMDA Receptor Functions
por: Popescu, Gabriela K., et al.
Publicado: (2010)

Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting
por: Oniani, Tengiz, et al.
Publicado: (2022)

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
por: Pfeiffer, Martin J., et al.
Publicado: (2018)

Cardiac Subtype-Specific Modeling of K(v)1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells
por: Marczenke, Maike, et al.
Publicado: (2017)

Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin
por: Daane, Jacob M., et al.
Publicado: (2018)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lkrkdocmdhhsl54ik6jd6bgmsq