Cargando…

The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization

BACKGROUND: Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder affecting millions worldwide. Due to the complexity of its pathogenesis, the treatment options for IBD are limited. This study focuses on ELF4, a member of the ETS transcription factor family, as a target to elucidate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Meiwan, Chen, Peiyu, Peng, Baoling, Cheng, Yang, Xie, Jing, Hou, Ziang, Chen, Huan, Ye, Liping, Li, Huiwen, Wang, Hongli, Ren, Lu, Xiong, Liya, Geng, Lanlan, Gong, Sitang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657822/ https://www.ncbi.nlm.nih.gov/pubmed/38022496 http://dx.doi.org/10.3389/fimmu.2023.1270411

Ejemplares similares

Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells
por: Xie, Jing, et al.
Publicado: (2021)

miR-34a induces neutrophil apoptosis by regulating Cdc42-WASP-Arp2/3 pathway-mediated F-actin remodeling and ROS production
por: Cao, Meiwan, et al.
Publicado: (2022)

The Mechanism of miR-155/miR-15b Axis Contributed to Apoptosis of CD34+ Cells by Upregulation of PD-L1 in Myelodysplastic Syndromes
por: Cao, MeiWan, et al.
Publicado: (2023)

CD103 Promotes the Pro-inflammatory Response of Gastric Resident CD4(+) T Cell in Helicobacter pylori-Positive Gastritis
por: Chen, Peiyu, et al.
Publicado: (2020)

ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer
por: Luk, Ian Y., et al.
Publicado: (2018)

Transcript Profiling of Elf5(+/−) Mammary Glands during Pregnancy Identifies Novel Targets of Elf5
por: Rogers, Renee L., et al.
Publicado: (2010)

Regulation of the human LAT gene by the Elf-1 transcription factor
por: Finco, Timothy S, et al.
Publicado: (2006)

Roles and regulations of the ETS transcription factor ELF4/MEF
por: Suico, Mary Ann, et al.
Publicado: (2017)

Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma
por: Cheng, Meixiong, et al.
Publicado: (2020)

HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome
por: Chen, Nini, et al.
Publicado: (2023)

Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea
por: Daniels, Jan-Peter, et al.
Publicado: (2009)

The Transcription Factor Elf3 Is Essential for a Successful Mesenchymal to Epithelial Transition
por: Sengez, Burcu, et al.
Publicado: (2019)

Clinical Significance of CD147 in Children with Inflammatory Bowel Disease
por: Wang, Hongli, et al.
Publicado: (2020)

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
por: Czimmerer, Zsolt, et al.
Publicado: (2018)

Evaluation of Monocarboxylate Transporter 4 in Inflammatory Bowel Disease and Its Potential Use as a Diagnostic Marker
por: He, Liying, et al.
Publicado: (2018)

Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies
por: Boti, Michaela A., et al.
Publicado: (2021)

The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition
por: Subbalakshmi, Ayalur Raghu, et al.
Publicado: (2023)

PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway
por: Cheng, Yang, et al.
Publicado: (2018)

Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN
por: Keermann, Maris, et al.
Publicado: (2015)

Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity
por: Ahmed, Afsar U., et al.
Publicado: (2015)

New isotope $^{227}$Rn and revised halflives for $^{223}$Rn and $^{226}$Rn
por: García-Borge, M J, et al.
Publicado: (1986)

Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease
por: Pan, Wenxu, et al.
Publicado: (2023)

ELFE at CERN
por: Burkhardt, H
Publicado: (1999)

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators
por: Raza, Sobia, et al.
Publicado: (2014)

Epithelial-Mesenchymal Transition Induces GSDME Transcriptional Activation for Inflammatory Pyroptosis
por: Jia, Chenqiang, et al.
Publicado: (2021)

Lactate-driven macrophage polarization in the inflammatory microenvironment alleviates intestinal inflammation
por: Zhou, Hai-Cun, et al.
Publicado: (2022)

Activation of the inflammatory transcription factor nuclear factor interleukin-6 during inflammatory and psychological stress in the brain
por: Fuchs, Franziska, et al.
Publicado: (2013)

Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids
Publicado: (1995)

Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function
por: Zhang, Shunxian, et al.
Publicado: (2019)

New isotope $^{227}$Rn and revised half lives for $^{223}$Rn and $^{226}$Rn
por: Nybø, K
Publicado: (1987)

Effectiveness of Dietary Allergen Exclusion Therapy on Eosinophilic Colitis in Chinese Infants and Young Children ≤ 3 Years of Age
por: Yang, Min, et al.
Publicado: (2015)

Upregulation of signal transducer and activator of transcription 3 in dogs with chronic inflammatory enteropathies
por: Manz, Anita, et al.
Publicado: (2021)

CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis
por: Xu, Zhaohui, et al.
Publicado: (2020)

Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation
por: Calero-Nieto, Fernando J., et al.
Publicado: (2010)

Natural variants of ELF3 affect thermomorphogenesis by transcriptionally modulating PIF4-dependent auxin response genes
por: Raschke, Anja, et al.
Publicado: (2015)

The hematopoietic regulator, ELF-1, enhances the transcriptional response to Interferon-β of the OAS1 anti-viral gene
por: Larsen, Steven, et al.
Publicado: (2015)

ETS transcription factor ELF3 (ESE‐1) is a cell cycle regulator in benign and malignant prostate
por: Archer, Leanne K., et al.
Publicado: (2022)

The ELFE programme and project
por: Laget, J M
Publicado: (1997)

The Nursery Elf (Poetry)
Publicado: (1881)

The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages
por: Kim, Hwijin
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o587sqodvra70ugnk2tbnser8s