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Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance, currently, there is no effective therapy to tr...

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Detalles Bibliográficos
Autores principales:	Zhang, Jia-Jia, Song, Chang-Geng, Wang, Miao, Zhang, Gai-Qin, Wang, Bin, Chen, Xi, Lin, Peng, Zhu, Yu-Meng, Sun, Zhi-Chuan, Wang, Ya-Zhou, Jiang, Jian-Li, Li, Ling, Yang, Xiang-Min, Chen, Zhi-Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657976/ https://www.ncbi.nlm.nih.gov/pubmed/38024852 http://dx.doi.org/10.1016/j.jpha.2023.06.008

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