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Therapeutic effect of aged garlic extract on gingivitis in dogs

Periodontal disease is one of the most common dental health problems in dogs. Clinical studies in humans have shown that aged garlic extract (AGE), which contains stable and water-soluble sulfur-containing bioactive compounds, improves the symptoms of periodontal diseases. Our previous study demonst...

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Autores principales: Takahashi, Kaori, Nango, Hiroshi, Ushijima, Mitsuyasu, Takashima, Miyuki, Nakamoto, Masato, Matsutomo, Toshiaki, Jikihara, Hiroshi, Arakawa, Nanami, Maki, Shinichiro, Yabuki, Akira, Endo, Yasuyuki, Yamato, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658002/
https://www.ncbi.nlm.nih.gov/pubmed/38026667
http://dx.doi.org/10.3389/fvets.2023.1277272
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author Takahashi, Kaori
Nango, Hiroshi
Ushijima, Mitsuyasu
Takashima, Miyuki
Nakamoto, Masato
Matsutomo, Toshiaki
Jikihara, Hiroshi
Arakawa, Nanami
Maki, Shinichiro
Yabuki, Akira
Endo, Yasuyuki
Yamato, Osamu
author_facet Takahashi, Kaori
Nango, Hiroshi
Ushijima, Mitsuyasu
Takashima, Miyuki
Nakamoto, Masato
Matsutomo, Toshiaki
Jikihara, Hiroshi
Arakawa, Nanami
Maki, Shinichiro
Yabuki, Akira
Endo, Yasuyuki
Yamato, Osamu
author_sort Takahashi, Kaori
collection PubMed
description Periodontal disease is one of the most common dental health problems in dogs. Clinical studies in humans have shown that aged garlic extract (AGE), which contains stable and water-soluble sulfur-containing bioactive compounds, improves the symptoms of periodontal diseases. Our previous study demonstrated that oral administration of AGE in healthy Beagle dogs at 90 mg/kg/day for 12 weeks had no adverse effects such as hemolytic anemia, which is well known to occur as a result of ingestion of Allium species, including onions and garlic, in dogs. However, the therapeutic potential of AGE in canine periodontal disease remains unclear. Accordingly, we investigated the therapeutic effects of AGE in Beagle dogs with mild gingivitis. Feeding 18 mg/kg/day of AGE for 8 weeks resulted in the improvement of gingival index score, level of volatile sulfur compounds in exhaled air, and enzyme activity of periodontal pathogens without any adverse effects on clinical signs and hematological and serum biochemical parameters. Moreover, AGE increased the concentration of salivary cathelicidin, an antimicrobial peptide that contributes to the oral innate immune response. These results suggest that AGE could be a potential therapeutic agent for canine gingivitis.
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spelling pubmed-106580022023-01-01 Therapeutic effect of aged garlic extract on gingivitis in dogs Takahashi, Kaori Nango, Hiroshi Ushijima, Mitsuyasu Takashima, Miyuki Nakamoto, Masato Matsutomo, Toshiaki Jikihara, Hiroshi Arakawa, Nanami Maki, Shinichiro Yabuki, Akira Endo, Yasuyuki Yamato, Osamu Front Vet Sci Veterinary Science Periodontal disease is one of the most common dental health problems in dogs. Clinical studies in humans have shown that aged garlic extract (AGE), which contains stable and water-soluble sulfur-containing bioactive compounds, improves the symptoms of periodontal diseases. Our previous study demonstrated that oral administration of AGE in healthy Beagle dogs at 90 mg/kg/day for 12 weeks had no adverse effects such as hemolytic anemia, which is well known to occur as a result of ingestion of Allium species, including onions and garlic, in dogs. However, the therapeutic potential of AGE in canine periodontal disease remains unclear. Accordingly, we investigated the therapeutic effects of AGE in Beagle dogs with mild gingivitis. Feeding 18 mg/kg/day of AGE for 8 weeks resulted in the improvement of gingival index score, level of volatile sulfur compounds in exhaled air, and enzyme activity of periodontal pathogens without any adverse effects on clinical signs and hematological and serum biochemical parameters. Moreover, AGE increased the concentration of salivary cathelicidin, an antimicrobial peptide that contributes to the oral innate immune response. These results suggest that AGE could be a potential therapeutic agent for canine gingivitis. Frontiers Media S.A. 2023-11-06 /pmc/articles/PMC10658002/ /pubmed/38026667 http://dx.doi.org/10.3389/fvets.2023.1277272 Text en Copyright © 2023 Takahashi, Nango, Ushijima, Takashima, Nakamoto, Matsutomo, Jikihara, Arakawa, Maki, Yabuki, Endo and Yamato. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Takahashi, Kaori
Nango, Hiroshi
Ushijima, Mitsuyasu
Takashima, Miyuki
Nakamoto, Masato
Matsutomo, Toshiaki
Jikihara, Hiroshi
Arakawa, Nanami
Maki, Shinichiro
Yabuki, Akira
Endo, Yasuyuki
Yamato, Osamu
Therapeutic effect of aged garlic extract on gingivitis in dogs
title Therapeutic effect of aged garlic extract on gingivitis in dogs
title_full Therapeutic effect of aged garlic extract on gingivitis in dogs
title_fullStr Therapeutic effect of aged garlic extract on gingivitis in dogs
title_full_unstemmed Therapeutic effect of aged garlic extract on gingivitis in dogs
title_short Therapeutic effect of aged garlic extract on gingivitis in dogs
title_sort therapeutic effect of aged garlic extract on gingivitis in dogs
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658002/
https://www.ncbi.nlm.nih.gov/pubmed/38026667
http://dx.doi.org/10.3389/fvets.2023.1277272
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