HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status

Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclus...

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Detalles Bibliográficos
Autores principales: Sun, Yali, Yang, Yongfang, Ye, Zhuoyi, Sun, Tongwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658041/
https://www.ncbi.nlm.nih.gov/pubmed/38028642
http://dx.doi.org/10.1016/j.jointm.2023.04.003
Descripción
Sumario:Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclusive. This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials, with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis.

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