HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status

Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclus...

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Detalles Bibliográficos
Autores principales: Sun, Yali, Yang, Yongfang, Ye, Zhuoyi, Sun, Tongwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658041/
https://www.ncbi.nlm.nih.gov/pubmed/38028642
http://dx.doi.org/10.1016/j.jointm.2023.04.003
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author Sun, Yali
Yang, Yongfang
Ye, Zhuoyi
Sun, Tongwen
author_facet Sun, Yali
Yang, Yongfang
Ye, Zhuoyi
Sun, Tongwen
author_sort Sun, Yali
collection PubMed
description Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclusive. This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials, with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis.
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spelling pubmed-106580412023-06-08 HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status Sun, Yali Yang, Yongfang Ye, Zhuoyi Sun, Tongwen J Intensive Med Review Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclusive. This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials, with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis. Elsevier 2023-06-08 /pmc/articles/PMC10658041/ /pubmed/38028642 http://dx.doi.org/10.1016/j.jointm.2023.04.003 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Sun, Yali
Yang, Yongfang
Ye, Zhuoyi
Sun, Tongwen
HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status
title HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status
title_full HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status
title_fullStr HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status
title_full_unstemmed HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status
title_short HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status
title_sort hat therapy for sepsis: a review of the therapeutic rationale and current clinical evaluation status
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658041/
https://www.ncbi.nlm.nih.gov/pubmed/38028642
http://dx.doi.org/10.1016/j.jointm.2023.04.003
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