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Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Association for Laboratory Animal Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658090/ https://www.ncbi.nlm.nih.gov/pubmed/37331803 http://dx.doi.org/10.1538/expanim.22-0065 |
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author | Cerrah, Serkan Akbas, Nergis Ozcicek, Fatih Mammadov, Renad Altuner, Durdu Suleyman, Halis Bulut, Seval |
author_facet | Cerrah, Serkan Akbas, Nergis Ozcicek, Fatih Mammadov, Renad Altuner, Durdu Suleyman, Halis Bulut, Seval |
author_sort | Cerrah, Serkan |
collection | PubMed |
description | Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers. |
format | Online Article Text |
id | pubmed-10658090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106580902023-01-01 Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation Cerrah, Serkan Akbas, Nergis Ozcicek, Fatih Mammadov, Renad Altuner, Durdu Suleyman, Halis Bulut, Seval Exp Anim Original Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers. Japanese Association for Laboratory Animal Science 2023-06-19 2023 /pmc/articles/PMC10658090/ /pubmed/37331803 http://dx.doi.org/10.1538/expanim.22-0065 Text en ©2023 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Cerrah, Serkan Akbas, Nergis Ozcicek, Fatih Mammadov, Renad Altuner, Durdu Suleyman, Halis Bulut, Seval Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation |
title | Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation |
title_full | Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation |
title_fullStr | Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation |
title_full_unstemmed | Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation |
title_short | Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation |
title_sort | effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658090/ https://www.ncbi.nlm.nih.gov/pubmed/37331803 http://dx.doi.org/10.1538/expanim.22-0065 |
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