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Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation

Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those...

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Autores principales: Cerrah, Serkan, Akbas, Nergis, Ozcicek, Fatih, Mammadov, Renad, Altuner, Durdu, Suleyman, Halis, Bulut, Seval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658090/
https://www.ncbi.nlm.nih.gov/pubmed/37331803
http://dx.doi.org/10.1538/expanim.22-0065
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author Cerrah, Serkan
Akbas, Nergis
Ozcicek, Fatih
Mammadov, Renad
Altuner, Durdu
Suleyman, Halis
Bulut, Seval
author_facet Cerrah, Serkan
Akbas, Nergis
Ozcicek, Fatih
Mammadov, Renad
Altuner, Durdu
Suleyman, Halis
Bulut, Seval
author_sort Cerrah, Serkan
collection PubMed
description Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers.
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spelling pubmed-106580902023-01-01 Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation Cerrah, Serkan Akbas, Nergis Ozcicek, Fatih Mammadov, Renad Altuner, Durdu Suleyman, Halis Bulut, Seval Exp Anim Original Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers. Japanese Association for Laboratory Animal Science 2023-06-19 2023 /pmc/articles/PMC10658090/ /pubmed/37331803 http://dx.doi.org/10.1538/expanim.22-0065 Text en ©2023 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original
Cerrah, Serkan
Akbas, Nergis
Ozcicek, Fatih
Mammadov, Renad
Altuner, Durdu
Suleyman, Halis
Bulut, Seval
Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
title Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
title_full Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
title_fullStr Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
title_full_unstemmed Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
title_short Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
title_sort effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658090/
https://www.ncbi.nlm.nih.gov/pubmed/37331803
http://dx.doi.org/10.1538/expanim.22-0065
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