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Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice

BACKGROUND: Morphine is a narcotic pain reliever that is prescribed to reduce postoperative pain and can produce reactive oxygen species (ROS). Therefore, it can have negative effects on spermatogenesis and male fertility. Vitamin E is an effective antioxidant which plays an important role in membra...

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Autores principales: Arjmand, Katayoon, Daneshi, Erfan, Pourmasumi, Soheila, Fathi, Fardin, Nasseri, Sherko, Sabeti, Parvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kerman University of Medical Sciences and Health Services 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658105/
https://www.ncbi.nlm.nih.gov/pubmed/38026720
http://dx.doi.org/10.34172/ahj.2023.1415
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author Arjmand, Katayoon
Daneshi, Erfan
Pourmasumi, Soheila
Fathi, Fardin
Nasseri, Sherko
Sabeti, Parvin
author_facet Arjmand, Katayoon
Daneshi, Erfan
Pourmasumi, Soheila
Fathi, Fardin
Nasseri, Sherko
Sabeti, Parvin
author_sort Arjmand, Katayoon
collection PubMed
description BACKGROUND: Morphine is a narcotic pain reliever that is prescribed to reduce postoperative pain and can produce reactive oxygen species (ROS). Therefore, it can have negative effects on spermatogenesis and male fertility. Vitamin E is an effective antioxidant which plays an important role in membrane lipid peroxidation due to increased ROS. The present study aimed to evaluate the effects of vitamin E and morphine on sperm parameters, level of malondialdehyde (MDA), and diameter of seminiferous tubules in morphine-treated mice. METHODS: In this experimental study, 80 mice were divided into ten groups (n=8) including control, normal saline, vehicle, morphine, various doses of vitamin E (100, 200, 300 mg/kg), and morphine plus vitamin E (100, 200, 300 mg/kg) groups. The groups were followed up for 30 consecutive days. Sperm parameters, testis weight, the diameter of seminiferous tubules, and the level of MDA were analyzed and compared. FINDINGS: Data analysis showed seminal parameters decreased significantly (excluding sperm count) and there was an increase in the level of MDA in morphine-treated mice compared with the normal saline group (P<0.05). Administration of E100 to morphinetreated mice did not show a significant difference in the evaluated parameters compared with the morphine group. However, E200 and E300 significantly reduced MDA and improved sperm parameters (P≤0.05). CONCLUSION: The results showed co-administration of vitamin E in high doses (200 & 300) could prevent the deleterious effects of morphine on some reproductive parameters and decrease the level of MDA in morphine-treated mice.
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spelling pubmed-106581052023-07-01 Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice Arjmand, Katayoon Daneshi, Erfan Pourmasumi, Soheila Fathi, Fardin Nasseri, Sherko Sabeti, Parvin Addict Health Original Article BACKGROUND: Morphine is a narcotic pain reliever that is prescribed to reduce postoperative pain and can produce reactive oxygen species (ROS). Therefore, it can have negative effects on spermatogenesis and male fertility. Vitamin E is an effective antioxidant which plays an important role in membrane lipid peroxidation due to increased ROS. The present study aimed to evaluate the effects of vitamin E and morphine on sperm parameters, level of malondialdehyde (MDA), and diameter of seminiferous tubules in morphine-treated mice. METHODS: In this experimental study, 80 mice were divided into ten groups (n=8) including control, normal saline, vehicle, morphine, various doses of vitamin E (100, 200, 300 mg/kg), and morphine plus vitamin E (100, 200, 300 mg/kg) groups. The groups were followed up for 30 consecutive days. Sperm parameters, testis weight, the diameter of seminiferous tubules, and the level of MDA were analyzed and compared. FINDINGS: Data analysis showed seminal parameters decreased significantly (excluding sperm count) and there was an increase in the level of MDA in morphine-treated mice compared with the normal saline group (P<0.05). Administration of E100 to morphinetreated mice did not show a significant difference in the evaluated parameters compared with the morphine group. However, E200 and E300 significantly reduced MDA and improved sperm parameters (P≤0.05). CONCLUSION: The results showed co-administration of vitamin E in high doses (200 & 300) could prevent the deleterious effects of morphine on some reproductive parameters and decrease the level of MDA in morphine-treated mice. Kerman University of Medical Sciences and Health Services 2023-07 2023-07-29 /pmc/articles/PMC10658105/ /pubmed/38026720 http://dx.doi.org/10.34172/ahj.2023.1415 Text en © 2023 Kerman University of Medical Sciences https://creativecommons.org/licenses/by-nc/3.0/This work is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Arjmand, Katayoon
Daneshi, Erfan
Pourmasumi, Soheila
Fathi, Fardin
Nasseri, Sherko
Sabeti, Parvin
Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice
title Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice
title_full Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice
title_fullStr Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice
title_full_unstemmed Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice
title_short Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice
title_sort evaluation of the effect of vitamin e on reproductive parameters in morphine-treated male mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658105/
https://www.ncbi.nlm.nih.gov/pubmed/38026720
http://dx.doi.org/10.34172/ahj.2023.1415
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