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Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians

Information on how 3D genome topology emerged in animal evolution, how stable it is during development, its role in the evolution of phenotypic novelties and how exactly it affects gene expression is highly debated. So far, data to address these questions are lacking with the exception of a few key...

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Detalles Bibliográficos
Autores principales: Rogers, Thea F, Simakov, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658181/
https://www.ncbi.nlm.nih.gov/pubmed/37815133
http://dx.doi.org/10.1093/bfgp/elad043
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author Rogers, Thea F
Simakov, Oleg
author_facet Rogers, Thea F
Simakov, Oleg
author_sort Rogers, Thea F
collection PubMed
description Information on how 3D genome topology emerged in animal evolution, how stable it is during development, its role in the evolution of phenotypic novelties and how exactly it affects gene expression is highly debated. So far, data to address these questions are lacking with the exception of a few key model species. Several gene regulatory mechanisms have been proposed, including scenarios where genome topology has little to no impact on gene expression, and vice versa. The ancient and diverse clade of spiralians may provide a crucial testing ground for such mechanisms. Sprialians have followed distinct evolutionary trajectories, with some clades experiencing genome expansions and/or large-scale genome rearrangements, and others undergoing genome contraction, substantially impacting their size and organisation. These changes have been associated with many phenotypic innovations in this clade. In this review, we describe how emerging genome topology data, along with functional tools, allow for testing these scenarios and discuss their predicted outcomes.
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spelling pubmed-106581812023-10-09 Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians Rogers, Thea F Simakov, Oleg Brief Funct Genomics Review Paper Information on how 3D genome topology emerged in animal evolution, how stable it is during development, its role in the evolution of phenotypic novelties and how exactly it affects gene expression is highly debated. So far, data to address these questions are lacking with the exception of a few key model species. Several gene regulatory mechanisms have been proposed, including scenarios where genome topology has little to no impact on gene expression, and vice versa. The ancient and diverse clade of spiralians may provide a crucial testing ground for such mechanisms. Sprialians have followed distinct evolutionary trajectories, with some clades experiencing genome expansions and/or large-scale genome rearrangements, and others undergoing genome contraction, substantially impacting their size and organisation. These changes have been associated with many phenotypic innovations in this clade. In this review, we describe how emerging genome topology data, along with functional tools, allow for testing these scenarios and discuss their predicted outcomes. Oxford University Press 2023-10-09 /pmc/articles/PMC10658181/ /pubmed/37815133 http://dx.doi.org/10.1093/bfgp/elad043 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Paper
Rogers, Thea F
Simakov, Oleg
Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians
title Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians
title_full Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians
title_fullStr Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians
title_full_unstemmed Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians
title_short Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians
title_sort emerging questions on the mechanisms and dynamics of 3d genome evolution in spiralians
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658181/
https://www.ncbi.nlm.nih.gov/pubmed/37815133
http://dx.doi.org/10.1093/bfgp/elad043
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