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Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients

INTRODUCTION: Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact of insulin resistance on CV risk after transplantation is not well defined. METHODS: We tested whether triglyceride-glucose (TyG) index, a su...

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Autores principales: Colladant, Mathilde, Chabannes, Melchior, Crepin, Thomas, Bamoulid, Jamal, Courivaud, Cécile, Ducloux, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658270/
https://www.ncbi.nlm.nih.gov/pubmed/38025208
http://dx.doi.org/10.1016/j.ekir.2023.08.021
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author Colladant, Mathilde
Chabannes, Melchior
Crepin, Thomas
Bamoulid, Jamal
Courivaud, Cécile
Ducloux, Didier
author_facet Colladant, Mathilde
Chabannes, Melchior
Crepin, Thomas
Bamoulid, Jamal
Courivaud, Cécile
Ducloux, Didier
author_sort Colladant, Mathilde
collection PubMed
description INTRODUCTION: Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact of insulin resistance on CV risk after transplantation is not well defined. METHODS: We tested whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, may predict posttransplant CVEs in a cohort of 715 consecutive KTRs all included 1 year after transplant. RESULTS: Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion was 4.75 ± 0.29 (median, 4.73 [4.14–5.84]). In multiple regression analysis, having a TyG above the median value was associated with higher body mass index (BMI), low high-density lipoprotein (HDL) cholesterol level, and greater urinary protein excretion. A total of 127 CVEs (17.7%) occurred during the study period. In univariate analysis, TyG was strongly associated with CVE occurrence (hazard ratio [HR] 2.06, 95% CI 1.42–3.50, for each increase of 0.1 in TyG, P < 0.001). The best predictive value was 4.87 (HR 6.32, 95% CI 3.30–12.11, P < 0.001). The risk of CVE gradually increased with higher TyG index (quartile 2, HR 1.71, 95% CI 0.84–5.20, P = 0.139; quartile 3, HR 3.12, 95% CI 1.61–6.02, P < 0.001; quartile 4, HR 7.46, 95% CI 4.03–13.80, P < 0.001, vs. quartile 1). TyG remained associated with CVE in multivariate analysis (HR 2.11, 95% CI 1.22–3.68, for each increase of 0.1 in TyG, P < 0.001). CONCLUSION: Insulin resistance, as measured by the TyG index is strongly associated with CVE in KTRs. Improving insulin sensitivity seems to be a major issue to prevent CV morbidity and mortality in this high-risk population.
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spelling pubmed-106582702023-08-23 Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients Colladant, Mathilde Chabannes, Melchior Crepin, Thomas Bamoulid, Jamal Courivaud, Cécile Ducloux, Didier Kidney Int Rep Clinical Research INTRODUCTION: Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact of insulin resistance on CV risk after transplantation is not well defined. METHODS: We tested whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, may predict posttransplant CVEs in a cohort of 715 consecutive KTRs all included 1 year after transplant. RESULTS: Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion was 4.75 ± 0.29 (median, 4.73 [4.14–5.84]). In multiple regression analysis, having a TyG above the median value was associated with higher body mass index (BMI), low high-density lipoprotein (HDL) cholesterol level, and greater urinary protein excretion. A total of 127 CVEs (17.7%) occurred during the study period. In univariate analysis, TyG was strongly associated with CVE occurrence (hazard ratio [HR] 2.06, 95% CI 1.42–3.50, for each increase of 0.1 in TyG, P < 0.001). The best predictive value was 4.87 (HR 6.32, 95% CI 3.30–12.11, P < 0.001). The risk of CVE gradually increased with higher TyG index (quartile 2, HR 1.71, 95% CI 0.84–5.20, P = 0.139; quartile 3, HR 3.12, 95% CI 1.61–6.02, P < 0.001; quartile 4, HR 7.46, 95% CI 4.03–13.80, P < 0.001, vs. quartile 1). TyG remained associated with CVE in multivariate analysis (HR 2.11, 95% CI 1.22–3.68, for each increase of 0.1 in TyG, P < 0.001). CONCLUSION: Insulin resistance, as measured by the TyG index is strongly associated with CVE in KTRs. Improving insulin sensitivity seems to be a major issue to prevent CV morbidity and mortality in this high-risk population. Elsevier 2023-08-23 /pmc/articles/PMC10658270/ /pubmed/38025208 http://dx.doi.org/10.1016/j.ekir.2023.08.021 Text en © 2023 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Clinical Research
Colladant, Mathilde
Chabannes, Melchior
Crepin, Thomas
Bamoulid, Jamal
Courivaud, Cécile
Ducloux, Didier
Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients
title Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients
title_full Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients
title_fullStr Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients
title_full_unstemmed Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients
title_short Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients
title_sort triglyceride-glucose index and cardiovascular events in kidney transplant recipients
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658270/
https://www.ncbi.nlm.nih.gov/pubmed/38025208
http://dx.doi.org/10.1016/j.ekir.2023.08.021
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