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Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients
INTRODUCTION: Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact of insulin resistance on CV risk after transplantation is not well defined. METHODS: We tested whether triglyceride-glucose (TyG) index, a su...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658270/ https://www.ncbi.nlm.nih.gov/pubmed/38025208 http://dx.doi.org/10.1016/j.ekir.2023.08.021 |
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author | Colladant, Mathilde Chabannes, Melchior Crepin, Thomas Bamoulid, Jamal Courivaud, Cécile Ducloux, Didier |
author_facet | Colladant, Mathilde Chabannes, Melchior Crepin, Thomas Bamoulid, Jamal Courivaud, Cécile Ducloux, Didier |
author_sort | Colladant, Mathilde |
collection | PubMed |
description | INTRODUCTION: Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact of insulin resistance on CV risk after transplantation is not well defined. METHODS: We tested whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, may predict posttransplant CVEs in a cohort of 715 consecutive KTRs all included 1 year after transplant. RESULTS: Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion was 4.75 ± 0.29 (median, 4.73 [4.14–5.84]). In multiple regression analysis, having a TyG above the median value was associated with higher body mass index (BMI), low high-density lipoprotein (HDL) cholesterol level, and greater urinary protein excretion. A total of 127 CVEs (17.7%) occurred during the study period. In univariate analysis, TyG was strongly associated with CVE occurrence (hazard ratio [HR] 2.06, 95% CI 1.42–3.50, for each increase of 0.1 in TyG, P < 0.001). The best predictive value was 4.87 (HR 6.32, 95% CI 3.30–12.11, P < 0.001). The risk of CVE gradually increased with higher TyG index (quartile 2, HR 1.71, 95% CI 0.84–5.20, P = 0.139; quartile 3, HR 3.12, 95% CI 1.61–6.02, P < 0.001; quartile 4, HR 7.46, 95% CI 4.03–13.80, P < 0.001, vs. quartile 1). TyG remained associated with CVE in multivariate analysis (HR 2.11, 95% CI 1.22–3.68, for each increase of 0.1 in TyG, P < 0.001). CONCLUSION: Insulin resistance, as measured by the TyG index is strongly associated with CVE in KTRs. Improving insulin sensitivity seems to be a major issue to prevent CV morbidity and mortality in this high-risk population. |
format | Online Article Text |
id | pubmed-10658270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106582702023-08-23 Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients Colladant, Mathilde Chabannes, Melchior Crepin, Thomas Bamoulid, Jamal Courivaud, Cécile Ducloux, Didier Kidney Int Rep Clinical Research INTRODUCTION: Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact of insulin resistance on CV risk after transplantation is not well defined. METHODS: We tested whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, may predict posttransplant CVEs in a cohort of 715 consecutive KTRs all included 1 year after transplant. RESULTS: Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion was 4.75 ± 0.29 (median, 4.73 [4.14–5.84]). In multiple regression analysis, having a TyG above the median value was associated with higher body mass index (BMI), low high-density lipoprotein (HDL) cholesterol level, and greater urinary protein excretion. A total of 127 CVEs (17.7%) occurred during the study period. In univariate analysis, TyG was strongly associated with CVE occurrence (hazard ratio [HR] 2.06, 95% CI 1.42–3.50, for each increase of 0.1 in TyG, P < 0.001). The best predictive value was 4.87 (HR 6.32, 95% CI 3.30–12.11, P < 0.001). The risk of CVE gradually increased with higher TyG index (quartile 2, HR 1.71, 95% CI 0.84–5.20, P = 0.139; quartile 3, HR 3.12, 95% CI 1.61–6.02, P < 0.001; quartile 4, HR 7.46, 95% CI 4.03–13.80, P < 0.001, vs. quartile 1). TyG remained associated with CVE in multivariate analysis (HR 2.11, 95% CI 1.22–3.68, for each increase of 0.1 in TyG, P < 0.001). CONCLUSION: Insulin resistance, as measured by the TyG index is strongly associated with CVE in KTRs. Improving insulin sensitivity seems to be a major issue to prevent CV morbidity and mortality in this high-risk population. Elsevier 2023-08-23 /pmc/articles/PMC10658270/ /pubmed/38025208 http://dx.doi.org/10.1016/j.ekir.2023.08.021 Text en © 2023 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Clinical Research Colladant, Mathilde Chabannes, Melchior Crepin, Thomas Bamoulid, Jamal Courivaud, Cécile Ducloux, Didier Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients |
title | Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients |
title_full | Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients |
title_fullStr | Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients |
title_full_unstemmed | Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients |
title_short | Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients |
title_sort | triglyceride-glucose index and cardiovascular events in kidney transplant recipients |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658270/ https://www.ncbi.nlm.nih.gov/pubmed/38025208 http://dx.doi.org/10.1016/j.ekir.2023.08.021 |
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