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Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases

INTRODUCTION: Patients with severe kidney diseases are at risk of complications from COVID-19; however, little is known about the effectiveness of COVID-19 vaccines in children and adolescents with kidney diseases. METHODS: We investigated the immunogenicity and safety of an accelerated 3-dose prima...

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Autores principales: Leung, Daniel, Chan, Eugene Yu-hin, Mu, Xiaofeng, Rosa Duque, Jaime S., Cheng, Samuel M.S., Ho, Fanny Tsz-wai, Tong, Pak-chiu, Lai, Wai-ming, Lee, Matthew H.L., Chim, Stella, Tam, Issan Y.S., Tsang, Leo C.H., Kwan, Kelvin K.H., Chung, Yuet, Wong, Howard H.W., Lee, Amos M.T., Li, Wing Yan, Sze, Summer T.K., Lam, Jennifer H.Y., Lee, Derek H.L., Chan, Sau Man, Tu, Wenwei, Peiris, Malik, Ma, Alison Lap-tak, Lau, Yu Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658278/
https://www.ncbi.nlm.nih.gov/pubmed/38025215
http://dx.doi.org/10.1016/j.ekir.2023.08.014
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author Leung, Daniel
Chan, Eugene Yu-hin
Mu, Xiaofeng
Rosa Duque, Jaime S.
Cheng, Samuel M.S.
Ho, Fanny Tsz-wai
Tong, Pak-chiu
Lai, Wai-ming
Lee, Matthew H.L.
Chim, Stella
Tam, Issan Y.S.
Tsang, Leo C.H.
Kwan, Kelvin K.H.
Chung, Yuet
Wong, Howard H.W.
Lee, Amos M.T.
Li, Wing Yan
Sze, Summer T.K.
Lam, Jennifer H.Y.
Lee, Derek H.L.
Chan, Sau Man
Tu, Wenwei
Peiris, Malik
Ma, Alison Lap-tak
Lau, Yu Lung
author_facet Leung, Daniel
Chan, Eugene Yu-hin
Mu, Xiaofeng
Rosa Duque, Jaime S.
Cheng, Samuel M.S.
Ho, Fanny Tsz-wai
Tong, Pak-chiu
Lai, Wai-ming
Lee, Matthew H.L.
Chim, Stella
Tam, Issan Y.S.
Tsang, Leo C.H.
Kwan, Kelvin K.H.
Chung, Yuet
Wong, Howard H.W.
Lee, Amos M.T.
Li, Wing Yan
Sze, Summer T.K.
Lam, Jennifer H.Y.
Lee, Derek H.L.
Chan, Sau Man
Tu, Wenwei
Peiris, Malik
Ma, Alison Lap-tak
Lau, Yu Lung
author_sort Leung, Daniel
collection PubMed
description INTRODUCTION: Patients with severe kidney diseases are at risk of complications from COVID-19; however, little is known about the effectiveness of COVID-19 vaccines in children and adolescents with kidney diseases. METHODS: We investigated the immunogenicity and safety of an accelerated 3-dose primary series of COVID-19 vaccination among 59 pediatric patients with chronic kidney disease (CKD) (mean age 12.9 years; 30 male) with or without immunosuppression, dialysis, or kidney transplant. Dosage was 0.1 ml BNT162b2 to those aged 5 to 11 years, and 0.3 ml BNT162b2 to those aged 11 to 18 years. RESULTS: Three doses of either vaccine type elicited significant antibody responses that included spike receptor-binding domain (S-RBD) IgG (90.5%–93.8% seropositive) and surrogate virus neutralization (geometric mean sVNT% level, 78.6%–79.3%). There were notable T cell responses. Weaker neutralization responses were observed among those on immunosuppression, especially those receiving higher number of immunosuppressants or on mycophenolate mofetil. Neutralization was reduced against Omicron BA.1 compared to wild type (WT, i.e., ancestral) (post-dose 3 sVNT% level; 82.7% vs. 27.4%; P < 0.0001). However, the T cell response against Omicron BA.1 was preserved, which likely confers protection against severe COVID-19. Infected patients exhibited hybrid immunity after vaccination, as evidenced by the higher Omicron BA.1 neutralization response among these infected patients who received 2 doses compared with those who were uninfected. Generally mild or moderate adverse reactions following vaccines were reported. CONCLUSION: An accelerated 3-dose primary series with BNT162b2 is immunogenic and safe in young children and adolescents with kidney diseases.
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spelling pubmed-106582782023-08-28 Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases Leung, Daniel Chan, Eugene Yu-hin Mu, Xiaofeng Rosa Duque, Jaime S. Cheng, Samuel M.S. Ho, Fanny Tsz-wai Tong, Pak-chiu Lai, Wai-ming Lee, Matthew H.L. Chim, Stella Tam, Issan Y.S. Tsang, Leo C.H. Kwan, Kelvin K.H. Chung, Yuet Wong, Howard H.W. Lee, Amos M.T. Li, Wing Yan Sze, Summer T.K. Lam, Jennifer H.Y. Lee, Derek H.L. Chan, Sau Man Tu, Wenwei Peiris, Malik Ma, Alison Lap-tak Lau, Yu Lung Kidney Int Rep Clinical Research INTRODUCTION: Patients with severe kidney diseases are at risk of complications from COVID-19; however, little is known about the effectiveness of COVID-19 vaccines in children and adolescents with kidney diseases. METHODS: We investigated the immunogenicity and safety of an accelerated 3-dose primary series of COVID-19 vaccination among 59 pediatric patients with chronic kidney disease (CKD) (mean age 12.9 years; 30 male) with or without immunosuppression, dialysis, or kidney transplant. Dosage was 0.1 ml BNT162b2 to those aged 5 to 11 years, and 0.3 ml BNT162b2 to those aged 11 to 18 years. RESULTS: Three doses of either vaccine type elicited significant antibody responses that included spike receptor-binding domain (S-RBD) IgG (90.5%–93.8% seropositive) and surrogate virus neutralization (geometric mean sVNT% level, 78.6%–79.3%). There were notable T cell responses. Weaker neutralization responses were observed among those on immunosuppression, especially those receiving higher number of immunosuppressants or on mycophenolate mofetil. Neutralization was reduced against Omicron BA.1 compared to wild type (WT, i.e., ancestral) (post-dose 3 sVNT% level; 82.7% vs. 27.4%; P < 0.0001). However, the T cell response against Omicron BA.1 was preserved, which likely confers protection against severe COVID-19. Infected patients exhibited hybrid immunity after vaccination, as evidenced by the higher Omicron BA.1 neutralization response among these infected patients who received 2 doses compared with those who were uninfected. Generally mild or moderate adverse reactions following vaccines were reported. CONCLUSION: An accelerated 3-dose primary series with BNT162b2 is immunogenic and safe in young children and adolescents with kidney diseases. Elsevier 2023-08-28 /pmc/articles/PMC10658278/ /pubmed/38025215 http://dx.doi.org/10.1016/j.ekir.2023.08.014 Text en © 2023 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Leung, Daniel
Chan, Eugene Yu-hin
Mu, Xiaofeng
Rosa Duque, Jaime S.
Cheng, Samuel M.S.
Ho, Fanny Tsz-wai
Tong, Pak-chiu
Lai, Wai-ming
Lee, Matthew H.L.
Chim, Stella
Tam, Issan Y.S.
Tsang, Leo C.H.
Kwan, Kelvin K.H.
Chung, Yuet
Wong, Howard H.W.
Lee, Amos M.T.
Li, Wing Yan
Sze, Summer T.K.
Lam, Jennifer H.Y.
Lee, Derek H.L.
Chan, Sau Man
Tu, Wenwei
Peiris, Malik
Ma, Alison Lap-tak
Lau, Yu Lung
Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases
title Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases
title_full Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases
title_fullStr Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases
title_full_unstemmed Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases
title_short Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases
title_sort humoral and cellular immunogenicity of 3 doses of bnt162b2 in children with kidney diseases
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658278/
https://www.ncbi.nlm.nih.gov/pubmed/38025215
http://dx.doi.org/10.1016/j.ekir.2023.08.014
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