Antisense-oligonucleotide co-micelles with tumor targeting peptides elicit therapeutic effects by inhibiting microRNA-21 in the glioblastoma animal models

INTRODUCTION: miRNA-21 (miR-21) is highly expressed in glioblastoma, facilitating tumor growth by blocking the expression of apoptosis-related genes. Therefore, an antisense microRNA oligonucleotide (AMO) against miR-21 was suggested as a therapeutic nucleic acid for glioblastoma. OBJECTIVES: AMO21...

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Detalles Bibliográficos
Autores principales: Lee, Youngki, Ha, Junkyu, Kim, Minkyung, Kang, Subin, Kang, Minji, Lee, Minhyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658310/
https://www.ncbi.nlm.nih.gov/pubmed/36632887
http://dx.doi.org/10.1016/j.jare.2023.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658310/
https://www.ncbi.nlm.nih.gov/pubmed/36632887
http://dx.doi.org/10.1016/j.jare.2023.01.005

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