The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients

Antibody kinetic curves obtained during a viral infection are often fitted using aggregated patient data, hiding the heterogeneity of individual humoral immune responses. Individual antibody responses can be modeled using the Wood equation and grouped according to their profile. Such modeling takes...

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Autores principales: Denis, J., Garnier, A., Claverie, D., De Laval, F., Attoumani, S., Tenebray, B., Durand, G.A., Coutard, B., Leparc-Goffart, I., Tournier, J.N., Briolant, S., Badaut, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658335/
https://www.ncbi.nlm.nih.gov/pubmed/38027965
http://dx.doi.org/10.1016/j.heliyon.2023.e21945
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author Denis, J.
Garnier, A.
Claverie, D.
De Laval, F.
Attoumani, S.
Tenebray, B.
Durand, G.A.
Coutard, B.
Leparc-Goffart, I.
Tournier, J.N.
Briolant, S.
Badaut, C.
author_facet Denis, J.
Garnier, A.
Claverie, D.
De Laval, F.
Attoumani, S.
Tenebray, B.
Durand, G.A.
Coutard, B.
Leparc-Goffart, I.
Tournier, J.N.
Briolant, S.
Badaut, C.
author_sort Denis, J.
collection PubMed
description Antibody kinetic curves obtained during a viral infection are often fitted using aggregated patient data, hiding the heterogeneity of individual humoral immune responses. Individual antibody responses can be modeled using the Wood equation and grouped according to their profile. Such modeling takes into account several important kinetic parameters, such as the day when antibody detection becomes positive [daypos], the day of the maximal response [daymax], the maximum antibody level [levelmax], and the day when antibody detection becomes negative [dayneg]. Potential associations between these profiles and studied factors can then be tested.
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spelling pubmed-106583352023-11-07 The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients Denis, J. Garnier, A. Claverie, D. De Laval, F. Attoumani, S. Tenebray, B. Durand, G.A. Coutard, B. Leparc-Goffart, I. Tournier, J.N. Briolant, S. Badaut, C. Heliyon Research Article Antibody kinetic curves obtained during a viral infection are often fitted using aggregated patient data, hiding the heterogeneity of individual humoral immune responses. Individual antibody responses can be modeled using the Wood equation and grouped according to their profile. Such modeling takes into account several important kinetic parameters, such as the day when antibody detection becomes positive [daypos], the day of the maximal response [daymax], the maximum antibody level [levelmax], and the day when antibody detection becomes negative [dayneg]. Potential associations between these profiles and studied factors can then be tested. Elsevier 2023-11-07 /pmc/articles/PMC10658335/ /pubmed/38027965 http://dx.doi.org/10.1016/j.heliyon.2023.e21945 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Denis, J.
Garnier, A.
Claverie, D.
De Laval, F.
Attoumani, S.
Tenebray, B.
Durand, G.A.
Coutard, B.
Leparc-Goffart, I.
Tournier, J.N.
Briolant, S.
Badaut, C.
The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients
title The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients
title_full The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients
title_fullStr The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients
title_full_unstemmed The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients
title_short The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients
title_sort wood equation allows consistent fitting of individual antibody-response profiles of zika virus or sars-cov-2 infected patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658335/
https://www.ncbi.nlm.nih.gov/pubmed/38027965
http://dx.doi.org/10.1016/j.heliyon.2023.e21945
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