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No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan‐induced inhibition of platelet aggregation response

BACKGROUND: A variant in the canine phosphodiesterase (PDE) 5A gene (PDE5A:E90K) is associated with decreased concentrations of circulating cyclic guanosine monophosphate (cGMP) and response to PDE5 inhibitor treatment. Pimobendan is a PDE inhibitor recommended for medical treatment of certain stage...

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Detalles Bibliográficos
Autores principales: Reimann, Maria J., Faisst, Daniel N., Knold, Mads, Meurs, Kathryn M., Stern, Joshua A., Cremer, Signe E., Møller, Jacob E., Ljungvall, Ingrid, Häggström, Jens, Olsen, Lisbeth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658480/
https://www.ncbi.nlm.nih.gov/pubmed/37743723
http://dx.doi.org/10.1111/jvim.16871