Engineering T cell receptor fusion proteins using nonviral CRISPR/Cas9 genome editing for cancer immunotherapy

Manufacture of chimeric antigen receptor (CAR)‐T cells usually involves the use of viral delivery systems to achieve high transgene expression. However, it can be costly and may result in random integration of the CAR into the genome, creating several disadvantages including variation in transgene e...

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Detalles Bibliográficos
Autores principales: Shu, Runzhe, Hammett, Maree, Evtimov, Vera, Pupovac, Aleta, Nguyen, Nhu‐Y, Islam, Rasa, Zhuang, Junli, Lee, Seyeong, Kang, Tae‐hun, Lee, Kyujun, Nisbet, Ian, Hudson, Peter, Lee, Jae Young, Boyd, Richard, Trounson, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Regular Issue Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658519/
https://www.ncbi.nlm.nih.gov/pubmed/38023726
http://dx.doi.org/10.1002/btm2.10571

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