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Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults
BACKGROUND: The most recent guideline on acute pulmonary embolism (PE) indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a PE event. However, effects on lung function or asthma risk have not been evaluated in the general population. METHOD...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658631/ https://www.ncbi.nlm.nih.gov/pubmed/38020573 http://dx.doi.org/10.1183/23120541.00631-2023 |
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author | Nilausen, Kristin Felicia Landt, Eskild Morten Al-Shuweli, Suzan Nordestgaard, Børge G. Bødtger, Uffe Dahl, Morten |
author_facet | Nilausen, Kristin Felicia Landt, Eskild Morten Al-Shuweli, Suzan Nordestgaard, Børge G. Bødtger, Uffe Dahl, Morten |
author_sort | Nilausen, Kristin Felicia |
collection | PubMed |
description | BACKGROUND: The most recent guideline on acute pulmonary embolism (PE) indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a PE event. However, effects on lung function or asthma risk have not been evaluated in the general population. METHODS: We tested whether individuals with a venous thromboembolism (VTE) encompassing PE and deep vein thrombosis (DVT) have reduced lung function, or greater risks of dyspnoea and asthma using data from 102 792 adults from the Copenhagen General Population Study. Diagnoses of PE, DVT and asthma were collected from the national Danish Patient Registry. Factor V Leiden and prothrombin G20210A gene variants were determined using TaqMan assays. RESULTS: Prevalences of PE, DVT and VTE were 2.2%, 3.6% and 5.2%, respectively. Individuals with VTE had forced expiratory volume in 1 s of 92% predicted compared with 96% pred in individuals without VTE (p<0.001). Individuals with VTE versus those without had adjusted OR (95% CI) for light, moderate and severe dyspnoea of 1.4 (1.2–1.6), 1.6 (1.4–1.8) and 1.7 (1.5–1.9), respectively. Individuals with VTE versus those without had an adjusted OR for asthma of 1.6 (95% CI 1.4–1.8). Factor V Leiden and prothrombin G20210A genotype also associated with increased risk of asthma (p for trend=0.002). Population-attributable fractions of severe dyspnoea and asthma due to VTE were 3.5% and 3.0%, respectively, in the population. CONCLUSION: Individuals with VTE have worse lung function and higher risks of severe dyspnoea and asthma, and may account for 3.5% and 3.0% of people with severe dyspnoea and asthma, respectively, in the general population. |
format | Online Article Text |
id | pubmed-10658631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-106586312023-11-20 Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults Nilausen, Kristin Felicia Landt, Eskild Morten Al-Shuweli, Suzan Nordestgaard, Børge G. Bødtger, Uffe Dahl, Morten ERJ Open Res Original Research Articles BACKGROUND: The most recent guideline on acute pulmonary embolism (PE) indicates possible long-term sequelae such as dyspnoea and chronic thromboembolic pulmonary hypertension after a PE event. However, effects on lung function or asthma risk have not been evaluated in the general population. METHODS: We tested whether individuals with a venous thromboembolism (VTE) encompassing PE and deep vein thrombosis (DVT) have reduced lung function, or greater risks of dyspnoea and asthma using data from 102 792 adults from the Copenhagen General Population Study. Diagnoses of PE, DVT and asthma were collected from the national Danish Patient Registry. Factor V Leiden and prothrombin G20210A gene variants were determined using TaqMan assays. RESULTS: Prevalences of PE, DVT and VTE were 2.2%, 3.6% and 5.2%, respectively. Individuals with VTE had forced expiratory volume in 1 s of 92% predicted compared with 96% pred in individuals without VTE (p<0.001). Individuals with VTE versus those without had adjusted OR (95% CI) for light, moderate and severe dyspnoea of 1.4 (1.2–1.6), 1.6 (1.4–1.8) and 1.7 (1.5–1.9), respectively. Individuals with VTE versus those without had an adjusted OR for asthma of 1.6 (95% CI 1.4–1.8). Factor V Leiden and prothrombin G20210A genotype also associated with increased risk of asthma (p for trend=0.002). Population-attributable fractions of severe dyspnoea and asthma due to VTE were 3.5% and 3.0%, respectively, in the population. CONCLUSION: Individuals with VTE have worse lung function and higher risks of severe dyspnoea and asthma, and may account for 3.5% and 3.0% of people with severe dyspnoea and asthma, respectively, in the general population. European Respiratory Society 2023-11-20 /pmc/articles/PMC10658631/ /pubmed/38020573 http://dx.doi.org/10.1183/23120541.00631-2023 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org |
spellingShingle | Original Research Articles Nilausen, Kristin Felicia Landt, Eskild Morten Al-Shuweli, Suzan Nordestgaard, Børge G. Bødtger, Uffe Dahl, Morten Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults |
title | Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults |
title_full | Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults |
title_fullStr | Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults |
title_full_unstemmed | Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults |
title_short | Venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults |
title_sort | venous thromboembolism associated with severe dyspnoea and asthma in 102 792 adults |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658631/ https://www.ncbi.nlm.nih.gov/pubmed/38020573 http://dx.doi.org/10.1183/23120541.00631-2023 |
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