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Research progress on branched-chain amino acid aminotransferases
Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells. Branched-chain amino acid aminotransferases play an important role in the metabolism of branched-chain a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658711/ https://www.ncbi.nlm.nih.gov/pubmed/38028625 http://dx.doi.org/10.3389/fgene.2023.1233669 |
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author | Chen, Can Naveed, Hassan Chen, Keping |
author_facet | Chen, Can Naveed, Hassan Chen, Keping |
author_sort | Chen, Can |
collection | PubMed |
description | Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells. Branched-chain amino acid aminotransferases play an important role in the metabolism of branched-chain amino acids. In this paper, the interspecific evolution and biological characteristics of branched-chain amino acid aminotransferases are introduced, the related research of branched-chain amino acid aminotransferases in animals, plants, microorganisms and humans is summarized and the molecular mechanism of branched-chain amino acid aminotransferase is analyzed. It has been found that branched-chain amino acid metabolism disorders are closely related to various diseases in humans and animals and plants, such as diabetes, cardiovascular diseases, brain diseases, neurological diseases and cancer. In particular, branched-chain amino acid aminotransferases play an important role in the development of various tumors. Branched-chain amino acid aminotransferases have been used as potential targets for various cancers. This article reviews the research on branched-chain amino acid aminotransferases, aiming to provide a reference for clinical research on targeted therapy for various diseases and different cancers. |
format | Online Article Text |
id | pubmed-10658711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106587112023-11-06 Research progress on branched-chain amino acid aminotransferases Chen, Can Naveed, Hassan Chen, Keping Front Genet Genetics Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells. Branched-chain amino acid aminotransferases play an important role in the metabolism of branched-chain amino acids. In this paper, the interspecific evolution and biological characteristics of branched-chain amino acid aminotransferases are introduced, the related research of branched-chain amino acid aminotransferases in animals, plants, microorganisms and humans is summarized and the molecular mechanism of branched-chain amino acid aminotransferase is analyzed. It has been found that branched-chain amino acid metabolism disorders are closely related to various diseases in humans and animals and plants, such as diabetes, cardiovascular diseases, brain diseases, neurological diseases and cancer. In particular, branched-chain amino acid aminotransferases play an important role in the development of various tumors. Branched-chain amino acid aminotransferases have been used as potential targets for various cancers. This article reviews the research on branched-chain amino acid aminotransferases, aiming to provide a reference for clinical research on targeted therapy for various diseases and different cancers. Frontiers Media S.A. 2023-11-06 /pmc/articles/PMC10658711/ /pubmed/38028625 http://dx.doi.org/10.3389/fgene.2023.1233669 Text en Copyright © 2023 Chen, Naveed and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Chen, Can Naveed, Hassan Chen, Keping Research progress on branched-chain amino acid aminotransferases |
title | Research progress on branched-chain amino acid aminotransferases |
title_full | Research progress on branched-chain amino acid aminotransferases |
title_fullStr | Research progress on branched-chain amino acid aminotransferases |
title_full_unstemmed | Research progress on branched-chain amino acid aminotransferases |
title_short | Research progress on branched-chain amino acid aminotransferases |
title_sort | research progress on branched-chain amino acid aminotransferases |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658711/ https://www.ncbi.nlm.nih.gov/pubmed/38028625 http://dx.doi.org/10.3389/fgene.2023.1233669 |
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