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Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review
BACKGROUND: The aim of this systematic review is to evaluate the changes in gut microbiota (GM) induced by the Ketogenic Diets (KD) as a potential underlying mechanism in the improvement of neurological diseases. METHODS: A comprehensive search was conducted on three electronic databases, including...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658738/ https://www.ncbi.nlm.nih.gov/pubmed/37981693 http://dx.doi.org/10.1186/s12937-023-00893-2 |
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author | Mazandarani, Mahdi Lashkarbolouk, Narges Ejtahed, Hanieh-Sadat Qorbani, Mostafa |
author_facet | Mazandarani, Mahdi Lashkarbolouk, Narges Ejtahed, Hanieh-Sadat Qorbani, Mostafa |
author_sort | Mazandarani, Mahdi |
collection | PubMed |
description | BACKGROUND: The aim of this systematic review is to evaluate the changes in gut microbiota (GM) induced by the Ketogenic Diets (KD) as a potential underlying mechanism in the improvement of neurological diseases. METHODS: A comprehensive search was conducted on three electronic databases, including PubMed/Medline, Web of Science, and Scopus until December 2022. The inclusion criteria were studies that described any changes in GM after consuming KD in neurological patients. Full text of studies such as clinical trials and cohorts were added. The quality assessment of cohort studies was conducted using the Newcastle–Ottawa Quality Assessment Scale and for the clinical trials using the Cochrane Collaboration tool. The search, screening, and data extraction were performed by two researchers independently. RESULTS: Thirteen studies examining the effects of the KD on the GM in neurological patients were included. Studies have shown that KD improves clinical outcomes by reducing disease severity and recurrence rates. An increase in Proteobacteria phylum, Escherichia, Bacteroides, Prevotella, Faecalibacterium, Lachnospira, Agaricus, and Mrakia genera and a reduction in Firmicutes, and Actinobacteria phyla, Eubacterium, Cronobacter, Saccharomyces, Claviceps, Akkermansia and Dialister genera were reported after KD. Studies showed a reduction in concentrations of fecal short-chain fatty acids and branched-chain fatty acids and an increase in beta Hydroxybutyrate, trimethylamine N-oxide, and N-acetylserotonin levels after KD. CONCLUSION: The KD prescribed in neurological patients has effectively altered the GM composition and GM-derived metabolites. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12937-023-00893-2. |
format | Online Article Text |
id | pubmed-10658738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106587382023-11-20 Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review Mazandarani, Mahdi Lashkarbolouk, Narges Ejtahed, Hanieh-Sadat Qorbani, Mostafa Nutr J Research BACKGROUND: The aim of this systematic review is to evaluate the changes in gut microbiota (GM) induced by the Ketogenic Diets (KD) as a potential underlying mechanism in the improvement of neurological diseases. METHODS: A comprehensive search was conducted on three electronic databases, including PubMed/Medline, Web of Science, and Scopus until December 2022. The inclusion criteria were studies that described any changes in GM after consuming KD in neurological patients. Full text of studies such as clinical trials and cohorts were added. The quality assessment of cohort studies was conducted using the Newcastle–Ottawa Quality Assessment Scale and for the clinical trials using the Cochrane Collaboration tool. The search, screening, and data extraction were performed by two researchers independently. RESULTS: Thirteen studies examining the effects of the KD on the GM in neurological patients were included. Studies have shown that KD improves clinical outcomes by reducing disease severity and recurrence rates. An increase in Proteobacteria phylum, Escherichia, Bacteroides, Prevotella, Faecalibacterium, Lachnospira, Agaricus, and Mrakia genera and a reduction in Firmicutes, and Actinobacteria phyla, Eubacterium, Cronobacter, Saccharomyces, Claviceps, Akkermansia and Dialister genera were reported after KD. Studies showed a reduction in concentrations of fecal short-chain fatty acids and branched-chain fatty acids and an increase in beta Hydroxybutyrate, trimethylamine N-oxide, and N-acetylserotonin levels after KD. CONCLUSION: The KD prescribed in neurological patients has effectively altered the GM composition and GM-derived metabolites. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12937-023-00893-2. BioMed Central 2023-11-20 /pmc/articles/PMC10658738/ /pubmed/37981693 http://dx.doi.org/10.1186/s12937-023-00893-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mazandarani, Mahdi Lashkarbolouk, Narges Ejtahed, Hanieh-Sadat Qorbani, Mostafa Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
title | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
title_full | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
title_fullStr | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
title_full_unstemmed | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
title_short | Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review |
title_sort | does the ketogenic diet improve neurological disorders by influencing gut microbiota? a systematic review |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658738/ https://www.ncbi.nlm.nih.gov/pubmed/37981693 http://dx.doi.org/10.1186/s12937-023-00893-2 |
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