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Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions
BACKGROUND: Long-range interactions between promoters and cis-regulatory elements, such as enhancers, play critical roles in gene regulation. However, the role of three-dimensional (3D) chromatin structure in orchestrating changes in transcriptional regulation during direct cell reprogramming is not...
Autores principales: | Wang, Miao, He, Bing, Hao, Yueling, Srinivasan, Divyaa, Shrinet, Jatin, Fraser, Peter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658794/ https://www.ncbi.nlm.nih.gov/pubmed/37981682 http://dx.doi.org/10.1186/s12915-023-01766-0 |
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