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A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa

Epidermolysis bullosa (EB) is a rare disorder caused by autosomal genetic variation. Its main clinical features include skin and mucous membrane blisters, erosion, repeated ulcers and scar formation. The lesions mostly involve the skin, oral cavity, digestive system and urinary system. Epidermolysis...

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Autores principales: Xu, Zhen, Zhang, Yong, Hu, Yanjiao, Xiu, Xia, Yang, Bowen, Huang, Tianqiao, Huang, Yichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658932/
https://www.ncbi.nlm.nih.gov/pubmed/38023129
http://dx.doi.org/10.3389/fonc.2023.1157563
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author Xu, Zhen
Zhang, Yong
Hu, Yanjiao
Xiu, Xia
Yang, Bowen
Huang, Tianqiao
Huang, Yichuan
author_facet Xu, Zhen
Zhang, Yong
Hu, Yanjiao
Xiu, Xia
Yang, Bowen
Huang, Tianqiao
Huang, Yichuan
author_sort Xu, Zhen
collection PubMed
description Epidermolysis bullosa (EB) is a rare disorder caused by autosomal genetic variation. Its main clinical features include skin and mucous membrane blisters, erosion, repeated ulcers and scar formation. The lesions mostly involve the skin, oral cavity, digestive system and urinary system. Epidermolysis bullosa complicated with esophageal stenosis is a common gastrointestinal manifestation of this disorder. Currently, there is no cure for EB, and thus symptomatic treatment is usually applied. Here we describe the case of a patient with recessive dystrophic EB complicated with severe esophageal stenosis. The narrow segment of esophagus was removed and the free part of jejunum was transplanted into the esophageal defect to reconstruct the esophagus and restore the patient’s normal swallowing. For patients with EB complicated with severe esophageal stenosis, surgical resection of the diseased esophagus and jejunal transplantation can be used to repair the esophageal and restore normal swallowing pathway, providing an effective treatment for this condition.
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spelling pubmed-106589322023-01-01 A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa Xu, Zhen Zhang, Yong Hu, Yanjiao Xiu, Xia Yang, Bowen Huang, Tianqiao Huang, Yichuan Front Oncol Oncology Epidermolysis bullosa (EB) is a rare disorder caused by autosomal genetic variation. Its main clinical features include skin and mucous membrane blisters, erosion, repeated ulcers and scar formation. The lesions mostly involve the skin, oral cavity, digestive system and urinary system. Epidermolysis bullosa complicated with esophageal stenosis is a common gastrointestinal manifestation of this disorder. Currently, there is no cure for EB, and thus symptomatic treatment is usually applied. Here we describe the case of a patient with recessive dystrophic EB complicated with severe esophageal stenosis. The narrow segment of esophagus was removed and the free part of jejunum was transplanted into the esophageal defect to reconstruct the esophagus and restore the patient’s normal swallowing. For patients with EB complicated with severe esophageal stenosis, surgical resection of the diseased esophagus and jejunal transplantation can be used to repair the esophageal and restore normal swallowing pathway, providing an effective treatment for this condition. Frontiers Media S.A. 2023-11-06 /pmc/articles/PMC10658932/ /pubmed/38023129 http://dx.doi.org/10.3389/fonc.2023.1157563 Text en Copyright © 2023 Xu, Zhang, Hu, Xiu, Yang, Huang and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xu, Zhen
Zhang, Yong
Hu, Yanjiao
Xiu, Xia
Yang, Bowen
Huang, Tianqiao
Huang, Yichuan
A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa
title A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa
title_full A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa
title_fullStr A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa
title_full_unstemmed A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa
title_short A case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa
title_sort case report of jejunum transplantation in the treatment of severe cervical esophageal stricture in patients with dystrophic epidermolysis bullosa
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658932/
https://www.ncbi.nlm.nih.gov/pubmed/38023129
http://dx.doi.org/10.3389/fonc.2023.1157563
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