Optimization of trans-4-hydroxyproline synthesis pathway by rearrangement center carbon metabolism in Escherichia coli

BACKGROUND: trans-4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production remains challenging due to the low production efficiency of T-4-HYP. This study focused on designing the key nodes of anabolic pathway to enhance carbon f...

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Detalles Bibliográficos
Autores principales: Gong, Yu, Wang, Ruiqi, Ma, Ling, Wang, Shuo, Li, Changgeng, Xu, Qingyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659092/
https://www.ncbi.nlm.nih.gov/pubmed/37986164
http://dx.doi.org/10.1186/s12934-023-02236-6

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