Enhancing isoprenol production by systematically tuning metabolic pathways using CRISPR interference in E. coli

Regulation of metabolic gene expression is crucial for maximizing bioproduction titers. Recent engineering tools including CRISPR/Cas9, CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa) have enabled effective knock-out, knock-down, and overexpression of endogenous pathway genes, respect...

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Detalles Bibliográficos
Autores principales: Kim, Jinho, Lee, Taek Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659101/
https://www.ncbi.nlm.nih.gov/pubmed/38026852
http://dx.doi.org/10.3389/fbioe.2023.1296132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659101/
https://www.ncbi.nlm.nih.gov/pubmed/38026852
http://dx.doi.org/10.3389/fbioe.2023.1296132

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