Longitudinal multi-functional analysis identified responses of T cells, B cells, and monocytes as hallmarks of immunotherapy tolerance in patients with merkel cell carcinoma

PURPOSE: Merkel cell carcinoma (MCC) is a neuroendocrine carcinoma originating in the skin. Studies are needed to determine the mechanisms of immune escape in patients with MCC, and malignant cell conditions that promote immune evasion. METHODS: We used Single-cell RNA sequencing (scRNA-seq) to dete...

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Detalles Bibliográficos
Autores principales: Tao, Quyuan, Du, Jia-xin, Zhang, Shijing, Lin, Wenjia, Luo, Yongxin, Liu, Ying, Zeng, Jingyan, Chen, Xin-lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659156/
https://www.ncbi.nlm.nih.gov/pubmed/37983224
http://dx.doi.org/10.1371/journal.pone.0293922

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