Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques

A vaccine that can achieve protective immunity prior to sexual debut is critical to prevent the estimated 410,000 new HIV infections that occur yearly in adolescents. As children living with HIV can make broadly neutralizing antibody (bnAb) responses in plasma at a faster rate than adults, early chi...

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Detalles Bibliográficos
Autores principales: Nelson, Ashley N., Shen, Xiaoying, Vekatayogi, Sravani, Zhang, Shiyu, Ozorowski, Gabriel, Dennis, Maria, Sewall, Leigh M., Milligan, Emma, Davis, Dominique, Cross, Kaitlyn A., Chen, Yue, van Schooten, Jelle, Eudailey, Joshua, Isaac, John, Memon, Saad, Weinbaum, Carolyn, Stanfield-Oakley, Sherry, Byrd, Alliyah, Chutkan, Suni, Berendam, Stella, Cronin, Kenneth, Yasmeen, Anila, Alam, S. Munir, LaBranche, Celia C., Rogers, Kenneth, Shirreff, Lisa, Cupo, Albert, Derking, Ronald, Villinger, Francois, Klasse, Per Johan, Ferrari, Guido, Williams, Wilton B., Hudgens, Michael G., Ward, Andrew B., Montefiori, David C., Van Rompay, Koen K.A., Wiehe, Kevin, Moore, John P., Sanders, Rogier W., De Paris, Kristina, Permar, Sallie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659289/
https://www.ncbi.nlm.nih.gov/pubmed/37986885
http://dx.doi.org/10.1101/2023.11.07.565306

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