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Selection of experience for memory by hippocampal sharp wave ripples

A general wisdom is that experiences need to be tagged during learning for further consolidation. However, brain mechanisms that select experiences for lasting memory are not known. Combining large-scale neural recordings with a novel application of dimensionality reduction techniques, we observed t...

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Autores principales: Yang, Wannan, Sun, Chen, Huszár, Roman, Hainmueller, Thomas, Buzsáki, György
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659301/
https://www.ncbi.nlm.nih.gov/pubmed/37987008
http://dx.doi.org/10.1101/2023.11.07.565935
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author Yang, Wannan
Sun, Chen
Huszár, Roman
Hainmueller, Thomas
Buzsáki, György
author_facet Yang, Wannan
Sun, Chen
Huszár, Roman
Hainmueller, Thomas
Buzsáki, György
author_sort Yang, Wannan
collection PubMed
description A general wisdom is that experiences need to be tagged during learning for further consolidation. However, brain mechanisms that select experiences for lasting memory are not known. Combining large-scale neural recordings with a novel application of dimensionality reduction techniques, we observed that successive traversals in the maze were tracked by continuously drifting populations of neurons, providing neuronal signatures of both places visited and events encountered (trial number). When the brain state changed during reward consumption, sharp wave ripples (SPW-Rs) occurred on some trials and their unique spike content most often decoded the trial in which they occurred. In turn, during post-experience sleep, SPW-Rs continued to replay those trials that were reactivated most frequently during awake SPW-Rs. These findings suggest that replay content of awake SPW-Rs provides a tagging mechanism to select aspects of experience that are preserved and consolidated for future use.
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spelling pubmed-106593012023-11-20 Selection of experience for memory by hippocampal sharp wave ripples Yang, Wannan Sun, Chen Huszár, Roman Hainmueller, Thomas Buzsáki, György bioRxiv Article A general wisdom is that experiences need to be tagged during learning for further consolidation. However, brain mechanisms that select experiences for lasting memory are not known. Combining large-scale neural recordings with a novel application of dimensionality reduction techniques, we observed that successive traversals in the maze were tracked by continuously drifting populations of neurons, providing neuronal signatures of both places visited and events encountered (trial number). When the brain state changed during reward consumption, sharp wave ripples (SPW-Rs) occurred on some trials and their unique spike content most often decoded the trial in which they occurred. In turn, during post-experience sleep, SPW-Rs continued to replay those trials that were reactivated most frequently during awake SPW-Rs. These findings suggest that replay content of awake SPW-Rs provides a tagging mechanism to select aspects of experience that are preserved and consolidated for future use. Cold Spring Harbor Laboratory 2023-11-08 /pmc/articles/PMC10659301/ /pubmed/37987008 http://dx.doi.org/10.1101/2023.11.07.565935 Text en https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Yang, Wannan
Sun, Chen
Huszár, Roman
Hainmueller, Thomas
Buzsáki, György
Selection of experience for memory by hippocampal sharp wave ripples
title Selection of experience for memory by hippocampal sharp wave ripples
title_full Selection of experience for memory by hippocampal sharp wave ripples
title_fullStr Selection of experience for memory by hippocampal sharp wave ripples
title_full_unstemmed Selection of experience for memory by hippocampal sharp wave ripples
title_short Selection of experience for memory by hippocampal sharp wave ripples
title_sort selection of experience for memory by hippocampal sharp wave ripples
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659301/
https://www.ncbi.nlm.nih.gov/pubmed/37987008
http://dx.doi.org/10.1101/2023.11.07.565935
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