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Dual effects of the small-conductance Ca(2+)-activated K(+) current on human atrial electrophysiology and Ca(2+)-driven arrhythmogenesis: an in silico study

By sensing changes in intracellular Ca(2+), small-conductance Ca(2+)-activated K(+) (SK) channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to-beat basis. Given their predominance in atria versus ventricles, SK channels are considered a promising atrial-selecti...

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Detalles Bibliográficos
Autores principales:	Herrera, Nathaniel T., Zhang, Xianwei, Ni, Haibo, Maleckar, Mary M., Heijman, Jordi, Dobrev, Dobromir, Grandi, Eleonora, Morotti, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659325/ https://www.ncbi.nlm.nih.gov/pubmed/37624096 http://dx.doi.org/10.1152/ajpheart.00362.2023

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