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APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest

Regulated cell cycle progression ensures homeostasis and prevents cancer. In proliferating cells, premature S phase entry is avoided by the E3 ubiquitin ligase APC/C (anaphase promoting complex/cyclosome), although the APC/C substrates whose degradation restrains G1-S progression are not fully known...

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Detalles Bibliográficos
Autores principales:	Mouery, Brandon L, Baker, Eliyambuya M, Mills, Christine A, Herring, Laura E, Fleifel, Dalia, Cook, Jeanette Gowen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659421/ https://www.ncbi.nlm.nih.gov/pubmed/37986787 http://dx.doi.org/10.1101/2023.11.09.566394

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