DLG1 functions upstream of SDCCAG3 and IFT20 to control targeting of polycystin-2 to the primary cilium

Polarized vesicular trafficking directs specific receptors and ion channels to the primary cilium, but the underlying mechanisms are poorly understood. Here we identify a key role for discs large MAGUK scaffold protein 1 (DLG1), a core component of the Scribble polarity complex, in regulating ciliar...

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Detalles Bibliográficos
Autores principales: Rezi, Csenge K., Aslanyan, Mariam G., Diwan, Gaurav D., Cheng, Tao, Chamlali, Mohamed, Junger, Kathrin, Anvarian, Zeinab, Lorentzen, Esben, Pauly, Kleo B., Afshar-Bahadori, Yasmin, Fernandes, Eduardo F. A., Qian, Feng, Tosi, Sébastien, Christensen, Søren T., Pedersen, Stine F., Strømgaard, Kristian, Russell, Robert B., Miner, Jeffrey H., Mahjoub, Moe R., Boldt, Karsten, Roepman, Ronald, Pedersen, Lotte B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659422/
https://www.ncbi.nlm.nih.gov/pubmed/37987012
http://dx.doi.org/10.1101/2023.11.10.566524

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