Cargando…

Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1

Antibodies have proven highly valuable for therapeutic development; however, they are typically poor candidates for applications that require activation of G protein-coupled receptors (GPCRs), the largest collection of targets for clinically approved drugs. Nanobodies (Nbs), the smallest antibody fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Emidio, Nayara Braga, Cheloha, Ross W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659424/
https://www.ncbi.nlm.nih.gov/pubmed/37986858
http://dx.doi.org/10.1101/2023.10.08.561411

Ejemplares similares