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Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR

Serotonin (5-hydroxytryptamine, 5-HT) acts via 13 different receptors in humans. Of these receptor subtypes, all but 5-HT(1e)R have confirmed roles in native tissue and are validated drug targets. Despite 5-HT(1e)R’s therapeutic potential and plausible druggability, the mechanisms of its activation...

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Detalles Bibliográficos
Autores principales:	Zilberg, Gregory, Parpounas, Alexandra K., Warren, Audrey L., Fiorillo, Bianca, Provasi, Davide, Filizola, Marta, Wacker, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659432/ https://www.ncbi.nlm.nih.gov/pubmed/37986777 http://dx.doi.org/10.1101/2023.10.05.561100

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