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Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study
BACKGROUND: People with HIV (PWH) have lower exercise capacity compared to HIV-uninfected peers, which may be explained by chronotropic incompetence (CI), the inability to increase heart rate during exercise. METHODS: The Exercise for Healthy Aging Study included adults ages 50–75 with and without H...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659453/ https://www.ncbi.nlm.nih.gov/pubmed/37986954 http://dx.doi.org/10.1101/2023.11.10.23298367 |
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author | Durstenfeld, Matthew S. Wilson, Melissa P. Jankowski, Catherine M. Ditzenberger, Grace L. Longenecker, Chris T. Erlandson, Kristine M. |
author_facet | Durstenfeld, Matthew S. Wilson, Melissa P. Jankowski, Catherine M. Ditzenberger, Grace L. Longenecker, Chris T. Erlandson, Kristine M. |
author_sort | Durstenfeld, Matthew S. |
collection | PubMed |
description | BACKGROUND: People with HIV (PWH) have lower exercise capacity compared to HIV-uninfected peers, which may be explained by chronotropic incompetence (CI), the inability to increase heart rate during exercise. METHODS: The Exercise for Healthy Aging Study included adults ages 50–75 with and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization to moderate or high intensity for 12 additional weeks. We compared adjusted heart rate reserve (AHRR; CI <80%) on cardiopulmonary exercise testing by HIV serostatus, and change from baseline to 12 and 24 weeks using mixed effects models. RESULTS: Among 32 PWH and 37 controls (median age 56, 7% female, mean BMI 28 kg/m(2)), 28% of PWH compared to 11% of controls had CI at baseline (p=0.067). AHRR was lower among PWH (91 vs 102%; difference 11%, 95% CI 2.5–19.7; p=0.01). At week 12, AHRR normalized among PWH (+8%, 95% CI 4–11; p<0.001) and was sustained at week 24 (+5, 95%CI 1–9; p=0.008) compared to no change among controls (95%CI −4 to 4; p=0.95; p(interaction)=0.004). After 24 weeks of exercise, only 15% PWH and 10% of controls had CI (p=0.70). CONCLUSIONS: Chronotropic incompetence contributes to reduced exercise capacity among PWH and improves with exercise training. |
format | Online Article Text |
id | pubmed-10659453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-106594532023-11-20 Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study Durstenfeld, Matthew S. Wilson, Melissa P. Jankowski, Catherine M. Ditzenberger, Grace L. Longenecker, Chris T. Erlandson, Kristine M. medRxiv Article BACKGROUND: People with HIV (PWH) have lower exercise capacity compared to HIV-uninfected peers, which may be explained by chronotropic incompetence (CI), the inability to increase heart rate during exercise. METHODS: The Exercise for Healthy Aging Study included adults ages 50–75 with and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization to moderate or high intensity for 12 additional weeks. We compared adjusted heart rate reserve (AHRR; CI <80%) on cardiopulmonary exercise testing by HIV serostatus, and change from baseline to 12 and 24 weeks using mixed effects models. RESULTS: Among 32 PWH and 37 controls (median age 56, 7% female, mean BMI 28 kg/m(2)), 28% of PWH compared to 11% of controls had CI at baseline (p=0.067). AHRR was lower among PWH (91 vs 102%; difference 11%, 95% CI 2.5–19.7; p=0.01). At week 12, AHRR normalized among PWH (+8%, 95% CI 4–11; p<0.001) and was sustained at week 24 (+5, 95%CI 1–9; p=0.008) compared to no change among controls (95%CI −4 to 4; p=0.95; p(interaction)=0.004). After 24 weeks of exercise, only 15% PWH and 10% of controls had CI (p=0.70). CONCLUSIONS: Chronotropic incompetence contributes to reduced exercise capacity among PWH and improves with exercise training. Cold Spring Harbor Laboratory 2023-11-10 /pmc/articles/PMC10659453/ /pubmed/37986954 http://dx.doi.org/10.1101/2023.11.10.23298367 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Durstenfeld, Matthew S. Wilson, Melissa P. Jankowski, Catherine M. Ditzenberger, Grace L. Longenecker, Chris T. Erlandson, Kristine M. Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study |
title | Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study |
title_full | Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study |
title_fullStr | Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study |
title_full_unstemmed | Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study |
title_short | Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study |
title_sort | chronotropic incompetence among people with hiv improves with exercise training in the exercise for healthy aging study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659453/ https://www.ncbi.nlm.nih.gov/pubmed/37986954 http://dx.doi.org/10.1101/2023.11.10.23298367 |
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