Epistasis regulates genetic control of cardiac hypertrophy

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The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic arc...

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Detalles Bibliográficos
Autores principales: Wang, Qianru, Tang, Tiffany M., Youlton, Nathan, Weldy, Chad S., Kenney, Ana M., Ronen, Omer, Hughes, J. Weston, Chin, Elizabeth T., Sutton, Shirley C., Agarwal, Abhineet, Li, Xiao, Behr, Merle, Kumbier, Karl, Moravec, Christine S., Tang, W. H. Wilson, Margulies, Kenneth B., Cappola, Thomas P., Butte, Atul J., Arnaout, Rima, Brown, James B., Priest, James R., Parikh, Victoria N., Yu, Bin, Ashley, Euan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659487/
https://www.ncbi.nlm.nih.gov/pubmed/37987017
http://dx.doi.org/10.1101/2023.11.06.23297858
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